电子显微镜下的阿尔茨海默病斑块

K. Dikranian
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引用次数: 2

摘要

阿尔茨海默病(AD)的特点是细胞外淀粉样蛋白-肽以弥漫性和纤维状斑块的形式聚集和沉积。50多年前,人类的电子显微镜研究已经确定了淀粉样斑块和神经原纤维缠结的结构。最近,ad型淀粉样变性的动物模型为研究ad型病理发展和表达过程中的斑块结构提供了极好的机会。来自各种过表达突变淀粉样前体蛋白的转基因小鼠的超微结构数据,突变的早老素,具有或不具有人类ApoE敲入异构体,与AD的经典电子显微镜结果高度相似。这篇综述试图从电子显微镜的角度来评估AD型病理的结构特征,特别是成熟的淀粉样斑块。生物医学评论2012;23:上行线。
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Electron microscopist’s view of the Alzheimer’s plaque
Alzheimer's disease (AD) is characterized by extracellular aggregation and deposition of Amyloid-beta peptide in the form of diffuse and fibrillar plaques. More than 50 years ago electron microscopic studies in humans have characterized the structure of the amyloid plaque and neurofibrillary tangles. More recently animal models of AD-type amyloidosis have provided excellent opportunities to study plaque structure during the development and expression of AD-type pathology. Ultrastructural data from a variety of transgenic mice overexpressing mutant amyloid precursor proteins, mutant presenilins, with or without human ApoE knock-in isoforms, are highly comparable to classical electron microscopic findings in AD. This review is an attempt to evaluate, from an electron microscopist’s point of view, the structural identity of AD type pathology, and the mature amyloid plaque in particular. Biomedical Reviews 2012; 23: 9-17.
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