Anan Yaghmur , Sana Ghayas , Habibullah Jan , Gokce Dicle Kalaycioglu , S. Moein Moghimi
{"title":"Omega-3脂肪酸纳米载体:表征和潜在的应用","authors":"Anan Yaghmur , Sana Ghayas , Habibullah Jan , Gokce Dicle Kalaycioglu , S. Moein Moghimi","doi":"10.1016/j.cocis.2023.101728","DOIUrl":null,"url":null,"abstract":"<div><p>Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (<em>ω</em>-3 PUFAs) and their precursors <em>ω</em>-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of <em>ω</em>-3 PUFAs, or from single <em>ω</em>-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.</p></div>","PeriodicalId":293,"journal":{"name":"Current Opinion in Colloid & Interface Science","volume":null,"pages":null},"PeriodicalIF":7.9000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1359029423000535/pdfft?md5=fa4e868d4a6aed6c5379ce7f88575b10&pid=1-s2.0-S1359029423000535-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Omega-3 fatty acid nanocarriers: Characterization and potential applications\",\"authors\":\"Anan Yaghmur , Sana Ghayas , Habibullah Jan , Gokce Dicle Kalaycioglu , S. Moein Moghimi\",\"doi\":\"10.1016/j.cocis.2023.101728\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (<em>ω</em>-3 PUFAs) and their precursors <em>ω</em>-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of <em>ω</em>-3 PUFAs, or from single <em>ω</em>-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.</p></div>\",\"PeriodicalId\":293,\"journal\":{\"name\":\"Current Opinion in Colloid & Interface Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1359029423000535/pdfft?md5=fa4e868d4a6aed6c5379ce7f88575b10&pid=1-s2.0-S1359029423000535-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Colloid & Interface Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1359029423000535\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Colloid & Interface Science","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1359029423000535","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Omega-3 fatty acid nanocarriers: Characterization and potential applications
Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and their precursors ω-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of ω-3 PUFAs, or from single ω-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.
期刊介绍：
Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications.
Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments.
Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
