新他克林衍生物及他克林-壳聚糖体系在退行性疾病中的应用

Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry Pub Date : 2019-11-14 DOI:10.3390/ecsoc-23-06499

Antonio Jesús Galera Carrillo, Antonio Franconetti-García, Francisca Cabrera-Escribano

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引用次数: 0

摘要

我们的研究重点是通过生物聚合物与合成的不同的他克林衍生物反应，合成具有与商品他克林相似或更高的AChE和BuChE抑制活性的新他克林衍生物和具有可调生物学性能的他克林-壳聚糖衍生物杂化物。所有的新化合物都通过核磁共振技术在溶液和固体状态下进行了表征。

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New Tacrine derivatives and Tacrine-Chitosan systems for application against degenerative diseases

Our research focuses on the synthesis of new tacrine derivatives with an expected similar or higher inhibitory activity of AChE and BuChE than commercial tacrine and hybrids tacrine-chitosan derivatives with tunable biological properties by reaction of the biopolymer with the different tacrine derivatives synthesized. All new compounds have been characterized by NMR techniques both in solution and in solid state.

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Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry

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