HOW WERE STRESS FAMILY AND INSR (INSULIN RECEPTOR) EXPRESSION IN POLYCYSTIC OVARY SYNDROME (PCOS) INSULIN RESISTANT IN MADURESE TRIBE?: INDONESIA

Introduce: Polycystic ovary syndrome (PCOS) is characterized by menstrual disorders (amenorrhea/oligomenorrhea), hirsutism, the appearance of acne, alopecia, and biochemical examination results showed an increase in androgen (testosterone). This study aimed to analyze family stress and expression of the gene INSR in insulin-resistant polycystic ovary syndrome (PCOS) in Madura. Methods: This is an analytic observational study with a study design case-control, the sample of 50 patients (PCOS cases) and 50 healthy women (Non-PCOS) in Madura Tribe, the research instrument used Kempe Family Stress Inventory (KFSI) and using in-depth interviews, followed by screening for SGOT, SGPT, BUN, Creatinin and GDA, PCR and RFLP on the INSR gene and continued sequencing on 10 samples. Result: The results of family stress reaction family with isolation, low self-esteem or depression average score was 56.4 (SD=4.23). The gene INSR had TT genotype 16.67%, TC 63.33%, and CC 20.00%, the control group had TT genotype 38.24%, TC 44.12%, and CC 17.65%, while in the case group T allele 48.33%, C allele 51.67% and T allele control group 56.67% and C allele 43.33%, based on statistical test chi-square in case and control groups, both genotype and allele had no significant difference (P-value> 0.05). Conclusion: The results showed family stress reaction with isolation, low self-esteem or depression. The expression result of INSR gene yielded was no difference between PCOS and healthy women. It needs to be continued because of racial differences between ethnic groups, especially in Indonesia.