Antimicrobial and anti-inflammatory effects of laser irradiation and Cholisal in the treatment of prosthetic stomatitis

Purpose: to study the effect of low-level laser therapy (LLLT) and preparation Cholisal at the microflora of oral mucous in prosthetic stomatitis (PS). Material and methods . Patients were divided into the following groups: Group 1 – control, without PS signs; Group 2 with PS had conventional treatment (sanitation of the oral cavity, removal of supra- and subgingival dental deposits, elimination of traumatic occlusion nodes, curettage of pathological pockets); Group 3 with PS had conventional treatment plus LLLT; Group 4 with PS had conventional treatment plus Cholisal; Group 5 with PS had conventional treatment plus LILI and Cholisal. The oral mucosa of patients with PS was irradiated externally every day for 7 days during 3 min. Matrix-VLOK laser with KL–VLOK head, wavelength of 0.63 mkm – an analog of helium-neon laser (red light) -, output power 2 mW was used. The irradiation dosage was calculated by the equation: D = ( P / S ) × t , where D is radiation dose, P (W) is radiation power on the wound surface, S (cm 2 ) is area of wound radiation, t (s) is exposure time. Thus, if the erosion surface area is 1–2 cm 2 , the irradiation dose has to be 3–6 J. Cholisal was applied topically before night sleep without subsequent LLLT. In the combined application of LLLT and Cholisal, irradiation was done in the morning . Results. It has been found out that LLLT reduces inflammatory processes and the level of microbial contamination in the oral mucous. Cholisal also reduces microbial contamination. The most effective technique for treating the oral mucous is a combined application of LLLT and Cholisal. Conclusion . The presented studies demonstrate effective outcomes in combined application of LLLT and Cholisal for reducing inflammatory processes and microbial contamination of the oral mucous in prosthetic stomatitis.