氙气在极端职业环境患者功能恢复与康复中的应用前景

I. Ushakov, A. O. Pyatibrat
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引用次数: 1

摘要

的相关性。在极端环境中工作的专业人员(军官、警察、飞行员、潜水员、消防员、救援人员等)很容易使他们的功能储备过度紧张,导致职业过度暴露甚至死亡。因此,优化在极端职业环境中工作的个体的功能状况是至关重要的。目的是分析氙在医学上的应用前景,包括促进极端职业环境下专业人员的功能优化和职业弹性。作者研究了过去十年在俄罗斯科学引文索引[https://elibrary.ru/]和PubMed [https://pubmed.ncbi.nlm.nih.gov]上发表的研究论文。结果和讨论。目前的研究分析显示,氙在成瘾药物、创伤后应激障碍的治疗、生理储备和职业恢复力的改善以及麻醉学方面的应用有许多研究。遗憾的是,我们对俄罗斯和国际出版物的回顾未能回答关于氙气作用背后的药理学机制的关键问题。一些研究论文在没有证据的情况下假设嗜离子性谷氨酸受体(nmda受体)可能参与抗伤害感受作用。氙是一个有希望的,可以适当地应用于在极端职业环境中工作的个人的治疗和康复。
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Prospects of Xenon Application in Functional Recovery and Rehabilitation of Patients Working in Extreme Occupational Environments
Relevance. Professionals working in extreme environments (army officers, police officers, pilots, divers, firefighters, rescue workers, etc.) are susceptible to overstraining their functional reserves, causing occupational overexposure or even death. It is therefore pivotal to optimize the functional condition of individuals working in extreme occupational environment.The objective is to analyse the prospects for xenon medical application, including to promote functional optimization and occupational resilience in professionals working in extreme occupational environment.Methods. The authors studied the research papers published in the Russian Science Citation Index [https://elibrary.ru/] and PubMed [https://pubmed.ncbi.nlm.nih.gov] over the last decade.Results and Discussion. Current research analysis has revealed numerous investigations regarding xenon application in addiction medicine, treatment of post-traumatic stress disorders, and improvement of physiological reserve and occupational resilience, as well as in anesthesiology. Regrettably, our review of Russian and international publications has failed to answer the pivotal issue regarding pharmacological mechanisms behind xenon action. A few research papers hypothesized without evidence that ionotropic glutamate receptors (NMDA-receptors) might be involved in antinociceptive effects.Conclusion. Xenon is a promise and can be appropriately applied in the treatment and rehabilitation of individuals working in extreme occupational environments.
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28
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