原子转移和氧化条件下取代吲哚的串联自由基加成反应

Jeffrey H. Byers, Jonathan A. Kosterlitz, Peter L. Steinberg
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引用次数: 1

摘要

二甲基丙二酸二甲基溴酸二甲酯光解或用Mn(OAc)3·2 H2O处理二甲基丙二酸二甲酯均可生成二甲基丙二酸二甲酯自由基。该自由基被加到附加于1-酰基或3-酰基吲哚的外环烯烃上,随后的环化分别生成1,2-或2,3-融合的吲哚衍生物。
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Tandem radical addition reactions to substituted indoles under atom-transfer and oxidative conditions

The dimethyl methylmalonyl radical was generated upon photolysis of dimethyl bromomethylmalonate or treatment of dimethyl methylmalonate with Mn(OAc)3·2 H2O. This radical was added to an exocyclic olefin appended to 1-acyl or 3-acyl indoles, with subsequent cyclization to generate 1,2- or 2,3- fused indole derivatives, respectively.

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