猫促智性调节性神经肽的药物-脑电图分析

Y. Fokin, S. Kharitonov, N. Karkischenko
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引用次数: 0

摘要

以促智性调节性神经肽为例,建立了猫脑在其作用下的归一化电图信息参数。结果证实了比较药物-脑电图分析与各种药物的定向作用。该药物组在脑电图上具有明显的稳定激活和益智作用,其特点是单向作用,与药效学和药代动力学数据一致。
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Pharmaco-EEG Analysis of Regulatory Neuropeptides with Nootropic Properties in Cats
Informative parameters of normalized electrograms of the brain of cats under the action of regulatory neuropeptides with nootropic properties were established using the example of the Semax drug. The results obtained were confirmed by a comparative pharmaco-EEG analysis with various pharmacological agents of  directed  action.  The  pronounced  stable  activating  and  nootropic  effects  of  this  pharmacological group in brain electrograms are distinguished by a unidirectional action that coincides with the data of pharmacodynamics and pharmacokinetics.
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