The release mechanism of insulin from soft gelatin capsule preparation

The kinetics of drug release from the test formulation was evaluated. Kitazawa, Higuchi, Hixson-Crowell and Fickian models were used. Mucin was processed from the small intestine of freshly slaughtered cow via precipitation with chilled acetone, air-drying and pulverization. Various preparations of insulin-mucin in the ratios 1:10, 1:15 and 1:25 were encapsulated. The in vitrorelease studies showed that the release rates decreased with increase in mucin concentration. The initial of releases were 41.4 mg in 10 min and 54.5 mg at 90 min , 24.2 mg in 10 min and 50.9 mg at 90 min and 34.0 mg in 10 min and 45.1 mg at 150 min for 1:10 1:15, 1:25 ratio preparations respectively. The release of insulin from the preparation generally followed the Higuchi diffusion model mechanisms with the exception of the formulation containing of insulin and mucin.