一种新的控制给药工具:经皮给药系统

A. V. Panval, B. Chaudhari, A. Velhal, V. Redasani
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引用次数: 1

摘要

经皮给药系统属于受控给药范畴。TDDS的主要目标是将药物以可控的速率通过皮肤进入体循环。TDDS用于克服口服给药过程中所面临的问题。与口服、静脉等不同类型的药物递送相比,TDDS提供了各种优势,它提供了药物的控制释放,避免了第一次通过代谢,提高了生物利用度,更好的患者依从性等等。小分子药物容易经皮给药。这些透皮贴片代表了皮肤科学和技术发展的关键成果。本文详细介绍了TDDS的介绍、优点和缺点、透皮贴剂的透皮透药原理、透皮贴剂的内容、类型和评价试验。
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A Novel Tool for Controlled Delivery: Transdermal Drug Delivery System
Transdermal Drug Delivery Systems comes under the category of Controlled drug delivery. The main goal of TDDS is to deliver the drug through skin into systemic circulation at controlled rate. TDDS is used to overcome the problems faced during drug administration through oral route. TDDS offers various advantages over different types of drug delivery like oral, IV etc. it provides control release of drug, avoids first pass metabolism, improves bioavailability, better patient compliance and many more. Drug with small molecules can be easily given by transdermal route. These Transdermal patches represents key outcome for growth in skin science and technology. This Review article explains all the detailed information of introduction of TDDS, its advantages and disadvantages, skin and drug permeation and its principle, contents of Transdermal patches it's types and evaluation test.
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