多草药凝胶制剂创面愈合活性的评价

Amrapali S. Kakade
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引用次数: 4

摘要

本研究的目的是评价复方凝胶制剂的创面愈合活性。以corboopol 940为凝胶基质制备不同浓度的凝胶。印楝叶提取物、三叶提取物和蜂蜜对冬季大鼠部分厚度烧伤模型的影响。所有的动物被分成六组。ⅰ组为对照组,ⅱ组为1%印楝凝胶,ⅲ组为1%原甘油三酯凝胶,ⅳ组为1%蜂蜜凝胶。V组用多草药凝胶治疗,IV组用市售制剂(参考标准)治疗。15天,所有凝胶局部应用。创面愈合活性评估的物理参数,即创面收缩和上皮化。该复方凝胶对伤口愈合活性有显著的促进作用。
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EVALUATION OF WOUND HEALING ACTIVITY OF POLYHERBAL GEL FORMULATION
The aim of present study was Evaluation of Wound Healing activity of Polyherbal Gel Formulation. The different concentration of gel was prepared by using corbopol 940 as a gel base. Azadirachta Indica leaves extract, Tridax procumbens leaves extract, and honey by using partial thickness burn wound model in winster rats. All animals were divided into six groups. Group I was control, Group II was treated by 1% of Azadirachta Indica gel, Group III was treated by 1% of Tridax procumbens gel, Group IV were treated by 1% Honey gel . Group V were treated by polyherbal gel and Group IV were treated by Marketed Preparetion (Reference Standard). For 15 days all gel applied topically. The wound healing activity evaluated by physical parameters namely wound contraction and epithelialization. The polyherbal gel shows significant effect on wound healing activity.
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