Clinical and radiographic evaluations of periodontal intrabony defects treated with enamel matrix derivative: a report of two cases

Background: Numerous studies evaluating the clinical and histologic effects of enamel matrix derivative (EMD) as an adjunct to periodontal surgical therapy have demonstrated significant improvements in clinical parameters, radiographic bone fill and periodontal regeneration. Case presentation: Two case reports are described that involved treatment of intrabony defects with periodontal flap surgery and placement of enamel matrix derivative. Each case was followed up after 12 months for clinical and radiographic evaluation. Both cases resulted in a reduction in probing depth (PD), a gain in clinical attachment level (CAL), an absence of bleeding on probing (BOP), unremarkable changes in gingival recession (REC) and radiographic evidence of bone fill. Conclusion: Treatment of an intrabony defect with periodontal flap surgery and EMD demonstrated bone fill as evidenced by radiographic evaluation performed after 12 months. Consistent improvements in the clinical parameters of CAL, PD and BOP were also noted.