{"title":"局部配方在使用无创装置治疗剖宫产疤痕中的疗效:一项对照试验","authors":"A. Abdullah, Rawya Al Kredly, M. Baguneid","doi":"10.2174/2213476x07999201228111027","DOIUrl":null,"url":null,"abstract":"\n\n Despite the availability of many topical formulations for scar treatment, an objective evaluation of\ntheir effect is lacking.\n\n\n\nTo assess the physiological, structural, and mechanical parameters of scar healing by a scar ointment (MEBOScar).\n\n\n\n\n45 patients from the Department of Obstetrics at Al Ain Hospital, UAE, with recently acquired Pfannenstiel scars\nwere recruited into this prospective, open-label, controlled study. Scar ointment was applied to a lateral third of the scar;\npositive control (silicone gel based topical) to the other lateral third; the middle third was left untreated (negative control).\nThe scars were evaluated at 4 time points up to 12 weeks using non-invasive devices and a scar questionnaire.\n\n\n\n In comparison with silicone gel, there was a significant reduction in trans epithelial water loss at weeks 2,4,8, and\n12 (p<0.001) and scar area at weeks 4, 8 and 12 (p<0.001) with scar ointment. The skin elasticity at week 4 was significantly\nincreased by scar ointment (p=0.007). By week 12, gross colour mismatch of the scar was described by 9% patients with\nscar ointment (24% with silicone gel, 42% with no treatment; p<0.001). There was significant improvement in scar texture\nwith scar ointment by week 12 (p<0.001).\n\n\n\n Scar ointment has beneficial effects on objective and subjective patient-reported parameters of Pfannenstiel\nscars.\n","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"27 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy of Topical Formulations in Healing of Caesarean Scars Using NonInvasive Devices: A Controlled Trial\",\"authors\":\"A. Abdullah, Rawya Al Kredly, M. Baguneid\",\"doi\":\"10.2174/2213476x07999201228111027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\n Despite the availability of many topical formulations for scar treatment, an objective evaluation of\\ntheir effect is lacking.\\n\\n\\n\\nTo assess the physiological, structural, and mechanical parameters of scar healing by a scar ointment (MEBOScar).\\n\\n\\n\\n\\n45 patients from the Department of Obstetrics at Al Ain Hospital, UAE, with recently acquired Pfannenstiel scars\\nwere recruited into this prospective, open-label, controlled study. Scar ointment was applied to a lateral third of the scar;\\npositive control (silicone gel based topical) to the other lateral third; the middle third was left untreated (negative control).\\nThe scars were evaluated at 4 time points up to 12 weeks using non-invasive devices and a scar questionnaire.\\n\\n\\n\\n In comparison with silicone gel, there was a significant reduction in trans epithelial water loss at weeks 2,4,8, and\\n12 (p<0.001) and scar area at weeks 4, 8 and 12 (p<0.001) with scar ointment. The skin elasticity at week 4 was significantly\\nincreased by scar ointment (p=0.007). By week 12, gross colour mismatch of the scar was described by 9% patients with\\nscar ointment (24% with silicone gel, 42% with no treatment; p<0.001). There was significant improvement in scar texture\\nwith scar ointment by week 12 (p<0.001).\\n\\n\\n\\n Scar ointment has beneficial effects on objective and subjective patient-reported parameters of Pfannenstiel\\nscars.\\n\",\"PeriodicalId\":8525,\"journal\":{\"name\":\"Applied Clinical Research, Clinical Trials and Regulatory Affairs\",\"volume\":\"27 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Clinical Research, Clinical Trials and Regulatory Affairs\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/2213476x07999201228111027\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2213476x07999201228111027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Efficacy of Topical Formulations in Healing of Caesarean Scars Using NonInvasive Devices: A Controlled Trial
Despite the availability of many topical formulations for scar treatment, an objective evaluation of
their effect is lacking.
To assess the physiological, structural, and mechanical parameters of scar healing by a scar ointment (MEBOScar).
45 patients from the Department of Obstetrics at Al Ain Hospital, UAE, with recently acquired Pfannenstiel scars
were recruited into this prospective, open-label, controlled study. Scar ointment was applied to a lateral third of the scar;
positive control (silicone gel based topical) to the other lateral third; the middle third was left untreated (negative control).
The scars were evaluated at 4 time points up to 12 weeks using non-invasive devices and a scar questionnaire.
In comparison with silicone gel, there was a significant reduction in trans epithelial water loss at weeks 2,4,8, and
12 (p<0.001) and scar area at weeks 4, 8 and 12 (p<0.001) with scar ointment. The skin elasticity at week 4 was significantly
increased by scar ointment (p=0.007). By week 12, gross colour mismatch of the scar was described by 9% patients with
scar ointment (24% with silicone gel, 42% with no treatment; p<0.001). There was significant improvement in scar texture
with scar ointment by week 12 (p<0.001).
Scar ointment has beneficial effects on objective and subjective patient-reported parameters of Pfannenstiel
scars.