局部配方在使用无创装置治疗剖宫产疤痕中的疗效:一项对照试验

A. Abdullah, Rawya Al Kredly, M. Baguneid
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引用次数: 0

摘要

尽管有许多用于疤痕治疗的局部配方,但缺乏对其效果的客观评估。评估疤痕软膏(MEBOScar)疤痕愈合的生理、结构和力学参数。来自阿联酋Al Ain医院产科的45名最近获得Pfannenstiel疤痕的患者被招募到这项前瞻性、开放标签、对照研究中。疤痕软膏涂抹在疤痕外侧的三分之一;阳性对照(硅凝胶为基础的局部)涂抹在另一侧的三分之一;中间三分之一不予治疗(阴性对照)。使用无创设备和疤痕问卷在4个时间点评估疤痕,直至12周。与硅胶相比,疤痕膏在第2、4、8和12周显著减少了上皮水分流失(p<0.001),在第4、8和12周显著减少了疤痕面积(p<0.001)。瘢痕膏组第4周皮肤弹性显著提高(p=0.007)。到第12周,9%的疤痕软膏患者出现了疤痕的总颜色不匹配(24%的患者使用了硅凝胶,42%的患者没有接受治疗;p < 0.001)。到第12周,疤痕膏显著改善了疤痕质地(p<0.001)。疤痕软膏对患者报告的Pfannenstielscars的客观和主观参数都有有益的影响。
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Efficacy of Topical Formulations in Healing of Caesarean Scars Using NonInvasive Devices: A Controlled Trial
Despite the availability of many topical formulations for scar treatment, an objective evaluation of their effect is lacking. To assess the physiological, structural, and mechanical parameters of scar healing by a scar ointment (MEBOScar). 45 patients from the Department of Obstetrics at Al Ain Hospital, UAE, with recently acquired Pfannenstiel scars were recruited into this prospective, open-label, controlled study. Scar ointment was applied to a lateral third of the scar; positive control (silicone gel based topical) to the other lateral third; the middle third was left untreated (negative control). The scars were evaluated at 4 time points up to 12 weeks using non-invasive devices and a scar questionnaire. In comparison with silicone gel, there was a significant reduction in trans epithelial water loss at weeks 2,4,8, and 12 (p<0.001) and scar area at weeks 4, 8 and 12 (p<0.001) with scar ointment. The skin elasticity at week 4 was significantly increased by scar ointment (p=0.007). By week 12, gross colour mismatch of the scar was described by 9% patients with scar ointment (24% with silicone gel, 42% with no treatment; p<0.001). There was significant improvement in scar texture with scar ointment by week 12 (p<0.001). Scar ointment has beneficial effects on objective and subjective patient-reported parameters of Pfannenstiel scars.
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