双膦酸盐作为生物化学屏障在下颌骨重建中的应用

Romzi Hanif, C. Hasan, Rahardjo Rahardjo, M. M. Rahmat
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引用次数: 0

摘要

目的:探讨局部应用双膦酸盐进行下颌骨重建后髂骨移植成骨和骨整合的积极效果。方法:一名22岁的女性患者以无痛的右脸颊肿块自2年来缓慢扩大而来。影像学检查示右侧下颌骨体至右侧下颌骨支混浊透光,组织病理学检查示骨化性纤维瘤。患者行下颌骨切除术后髂骨移植重建下颌骨。植骨用二膦酸盐(0.005 mg /ml唑来膦酸)浸泡3分钟,3分钟后用生理盐水冲洗,将植骨固定在重建板上。结果:术后随访第36周,手术部位未见感染、开裂迹象,影像学检查显示下颌骨移植物成骨、骨整合迹象。结论:局部应用双膦酸盐可促进下颌骨重建成骨和骨融合。
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Local application of biphosphonate as a biochemical barrier against bone graft resorption in mandibular reconstruction
Objective: This paper was aimed at examining the positive results of iliac bone graft osteogenesis and osteointegration following the local application of bisphosphonate in mandibular reconstruction. Methods: A 22-years-old female patient came with a complaint of pain-free right cheek mass that has enlarged slowly since 2 years. Radiographic examination shows cloudy radiolucent images in the right mandibular corpus to the right mandibular ramus, while histopathological examination indicates ossifying fibroma. Patient underwent mandibular resection followed by iliac bone graftbased mandibular reconstruction. Bone graft was immersed with bisphosphonate (zoledronate acid 0.005 mg /ml) for 3 minutes, then rinsed with saline in 3 minutes, followed by fixing bone graft on the reconstruction plate. Results: Postoperative follow up in the 36th week showed no signs of infection and dehiscence in the surgery site, and the radiographic examination indicated signs of osteogenesis and osteointegration of mandibular bone graft. Conclusion: Local application of biphosponate on bone graft promotes the favorable results of osteogenesis and osteointegration in mandibular reconstruction.
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16 weeks
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