{"title":"黄嘌呤代替。2. 一些(2-羟基烷基)茶碱三甲基铵的制备及其性质。","authors":"F. Vidal, T. Fand","doi":"10.1002/JPS.3030490813","DOIUrl":null,"url":null,"abstract":"A new and convenient method has been developed for the large scale preparation of (2-hydroxyethyl)trimethylammonium theophyllinate. 1 The synthesis of several (2-hydroxyalkyl)trimethylammonium theophyllinates was accomplished by the addition of trimethylamine to various epoxyalkanes and then reacting the resulting intermediate with theophylline or 8-substituted theophylline derivatives. Various properties of these compounds are described.","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":"6 1","pages":"535-8"},"PeriodicalIF":0.0000,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Substituted xanthines. 2. Preparation and properties of some (2-hydroxyalkyl)trimethylammonium theophyllinates.\",\"authors\":\"F. Vidal, T. Fand\",\"doi\":\"10.1002/JPS.3030490813\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A new and convenient method has been developed for the large scale preparation of (2-hydroxyethyl)trimethylammonium theophyllinate. 1 The synthesis of several (2-hydroxyalkyl)trimethylammonium theophyllinates was accomplished by the addition of trimethylamine to various epoxyalkanes and then reacting the resulting intermediate with theophylline or 8-substituted theophylline derivatives. Various properties of these compounds are described.\",\"PeriodicalId\":17210,\"journal\":{\"name\":\"Journal of the American Pharmaceutical Association. American Pharmaceutical Association\",\"volume\":\"6 1\",\"pages\":\"535-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1960-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Pharmaceutical Association. American Pharmaceutical Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/JPS.3030490813\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/JPS.3030490813","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Substituted xanthines. 2. Preparation and properties of some (2-hydroxyalkyl)trimethylammonium theophyllinates.
A new and convenient method has been developed for the large scale preparation of (2-hydroxyethyl)trimethylammonium theophyllinate. 1 The synthesis of several (2-hydroxyalkyl)trimethylammonium theophyllinates was accomplished by the addition of trimethylamine to various epoxyalkanes and then reacting the resulting intermediate with theophylline or 8-substituted theophylline derivatives. Various properties of these compounds are described.
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