富血小板纤维蛋白治疗药物相关性颌骨骨坏死随访2年

M. Hristamyan, V. Hristamyan
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引用次数: 0

摘要

富血小板纤维蛋白(PRF)在外科手术中的应用代表了治疗颌骨药物相关性骨坏死的一种新的替代方法。本报告报告了一例接受PRF治疗的患者。患者是一名76岁的男性,2018年因右侧下颚骨坏死在颌面外科诊所接受治疗。2012年,他被诊断患有前列腺癌,接受了双侧睾丸切除术,随后接受了Denosumab(商品名Prolia和Xgeva)治疗,这是一种单克隆抗体,可作为核因子kappa-Β配体(RANKL)抑制剂的受体激活剂。患者于2017年拔牙后被诊断为下颌骨药物相关性骨坏死。治疗是在保加利亚普罗夫迪夫圣乔治大学医院颌面外科诊所进行的。当最初的抗生素治疗失败时,使用PRF进行手术治疗。随访2年,干预区未发现复发性坏死灶。Biomed Rev 2020;31日:161 - 163
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Platelet-rich fibrin treatment of medication-related osteonecrosis of the jaw followed up for two years
The use of platelet-rich fibrin (PRF) in surgery represents a new alternative method of treatment of Medication-related osteonecrosis of the jaws. This report presents a case of a patient undergoing PRF treatment. The patient is a 76-year-old male who was admitted for treatment in 2018 at the Clinic for Maxillofacial Surgery with osteonecrosis of the lower jaw on the right side. In 2012, he was diagnosed with prostate cancer and underwent bilateral orchiectomy followed by a therapy with Denosumab (trade names Prolia and Xgeva), a monoclonal antibody that works as receptor activator of nuclear factor kappa-Β ligand (RANKL) inhibitor. The patient was diagnosed with medication-related osteonecrosis of the mandible jaw in 2017 after tooth extraction. The treatment was performed at the Clinic of Maxillofacial Surgery of St. George University Hospital, Plovdiv, Bulgaria. When initial antibiotic therapy failed, surgical therapy was undertaken using PRF. The patient was followed-up for two years and no osteonecrotic lesion was detected recurring in the intervention area. Biomed Rev 2020; 31: 161-163
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