{"title":"巴戟天对正常大鼠和链脲佐菌素诱导的糖尿病大鼠的降血糖和降血脂作用","authors":"Amine Azzane, Ayoub Amssayef, Mohamed Eddouks","doi":"10.2174/1871529X22666220513124452","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>The present work aimed to assess the antihyperglycemic and antihyperlipidemic effects of Moricandia suffruticosa.</p><p><strong>Background: </strong>Moricandia suffruticosa (M. suffruticosa) is used in traditional medicine.</p><p><strong>Objective: </strong>The present study investigated the antihyperglycemic and antidyslipidemic effects of M. suffruticosa and its effect on glycogen content in normoglycemic and hyperglycemic rats.</p><p><strong>Methods: </strong>The effect of the aqueous extract of M. suffruticosa (AEMS) at two doses of 100 and 140 mg/kg on blood glucose levels, lipid, lipoprotein profile, and glycogen content was examined in normal and streptozotocin (STZ)-induced diabetic rats. Moreover, preliminary phytochemical screening and quantification of phenolic, flavonoid, and tannin contents were carried out.</p><p><strong>Results: </strong>The results demonstrated that AEMS exhibits antihyperglycemic activity in diabetic rats during both acute and subchronic assays. Furthermore, AEMS revealed an antidyslipidemic effect concerning the level of triglycerides, total cholesterol, very-low-density lipoprotein (VLDL), and non-high-density lipoproteins (Non-HDL). In contrast, AEMS has not affected the value of glycemia, lipids, and lipoproteins in normal rats. In addition, AEMS is rich in several phytochemical compounds. Furthermore, AEMS revealed an important in vitro antioxidant activity.</p><p><strong>Conclusion: </strong>In conclusion, the study demonstrates that M. suffruticosa exhibits an important antihyperglycemic effect in diabetic rats.</p>","PeriodicalId":20586,"journal":{"name":"Proceedings of the Edinburgh Mathematical Society","volume":"30 1","pages":"58-66"},"PeriodicalIF":0.9000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antihyperglycemic and Antidyslipidemic Effect of <i>Moricandia Suffruticosa</i> in Normal and Streptozotocin-induced Diabetic Rats.\",\"authors\":\"Amine Azzane, Ayoub Amssayef, Mohamed Eddouks\",\"doi\":\"10.2174/1871529X22666220513124452\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>The present work aimed to assess the antihyperglycemic and antihyperlipidemic effects of Moricandia suffruticosa.</p><p><strong>Background: </strong>Moricandia suffruticosa (M. suffruticosa) is used in traditional medicine.</p><p><strong>Objective: </strong>The present study investigated the antihyperglycemic and antidyslipidemic effects of M. suffruticosa and its effect on glycogen content in normoglycemic and hyperglycemic rats.</p><p><strong>Methods: </strong>The effect of the aqueous extract of M. suffruticosa (AEMS) at two doses of 100 and 140 mg/kg on blood glucose levels, lipid, lipoprotein profile, and glycogen content was examined in normal and streptozotocin (STZ)-induced diabetic rats. Moreover, preliminary phytochemical screening and quantification of phenolic, flavonoid, and tannin contents were carried out.</p><p><strong>Results: </strong>The results demonstrated that AEMS exhibits antihyperglycemic activity in diabetic rats during both acute and subchronic assays. Furthermore, AEMS revealed an antidyslipidemic effect concerning the level of triglycerides, total cholesterol, very-low-density lipoprotein (VLDL), and non-high-density lipoproteins (Non-HDL). In contrast, AEMS has not affected the value of glycemia, lipids, and lipoproteins in normal rats. In addition, AEMS is rich in several phytochemical compounds. Furthermore, AEMS revealed an important in vitro antioxidant activity.</p><p><strong>Conclusion: </strong>In conclusion, the study demonstrates that M. suffruticosa exhibits an important antihyperglycemic effect in diabetic rats.</p>\",\"PeriodicalId\":20586,\"journal\":{\"name\":\"Proceedings of the Edinburgh Mathematical Society\",\"volume\":\"30 1\",\"pages\":\"58-66\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Edinburgh Mathematical Society\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://doi.org/10.2174/1871529X22666220513124452\",\"RegionNum\":3,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATHEMATICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Edinburgh Mathematical Society","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.2174/1871529X22666220513124452","RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATHEMATICS","Score":null,"Total":0}
Antihyperglycemic and Antidyslipidemic Effect of Moricandia Suffruticosa in Normal and Streptozotocin-induced Diabetic Rats.
Aims: The present work aimed to assess the antihyperglycemic and antihyperlipidemic effects of Moricandia suffruticosa.
Background: Moricandia suffruticosa (M. suffruticosa) is used in traditional medicine.
Objective: The present study investigated the antihyperglycemic and antidyslipidemic effects of M. suffruticosa and its effect on glycogen content in normoglycemic and hyperglycemic rats.
Methods: The effect of the aqueous extract of M. suffruticosa (AEMS) at two doses of 100 and 140 mg/kg on blood glucose levels, lipid, lipoprotein profile, and glycogen content was examined in normal and streptozotocin (STZ)-induced diabetic rats. Moreover, preliminary phytochemical screening and quantification of phenolic, flavonoid, and tannin contents were carried out.
Results: The results demonstrated that AEMS exhibits antihyperglycemic activity in diabetic rats during both acute and subchronic assays. Furthermore, AEMS revealed an antidyslipidemic effect concerning the level of triglycerides, total cholesterol, very-low-density lipoprotein (VLDL), and non-high-density lipoproteins (Non-HDL). In contrast, AEMS has not affected the value of glycemia, lipids, and lipoproteins in normal rats. In addition, AEMS is rich in several phytochemical compounds. Furthermore, AEMS revealed an important in vitro antioxidant activity.
Conclusion: In conclusion, the study demonstrates that M. suffruticosa exhibits an important antihyperglycemic effect in diabetic rats.
期刊介绍：
The Edinburgh Mathematical Society was founded in 1883 and over the years, has evolved into the principal society for the promotion of mathematics research in Scotland. The Society has published its Proceedings since 1884. This journal contains research papers on topics in a broad range of pure and applied mathematics, together with a number of topical book reviews.
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