自动癫痫发作检测

Arvind Dorai, K. Ponnambalam
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引用次数: 25

摘要

癫痫是一种严重的神经系统疾病,其特征是由于大脑中异常或过度的神经元活动而引起的反复无端发作。据估计,全世界有5000万人患有这种疾病,它被列为人类已知的第二大神经系统疾病,仅次于中风。通过对癫痫发作的早期和准确的检测,医生可以获得宝贵的时间来进行药物治疗和其他抗癫痫措施,以帮助减少这种致残性疾病的破坏性影响。时变的动态和高度的个体间变异性使癫痫发作状态的早期预测成为一项具有挑战性的任务。许多研究表明,脑电图信号确实具有有价值的信息,如果分析正确,可以帮助在癫痫患者发作之前预测其发作。分析了几种数学变换与癫痫发作预测的相关性,并进行了一系列实验来证明它们的优势。提出了新的算法来帮助澄清、监测和交叉验证脑电图信号的分类,以预测发作(即癫痫发作)状态,特别是大脑的发作前、发作间和发作后状态。这些新方法在检测临界状态之前的临界相的存在方面显示出有希望的结果。
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Automated epileptic seizure onset detection
Epilepsy is a serious neurological disorder characterized by recurrent unprovoked seizures due to abnormal or excessive neuronal activity in the brain. An estimated 50 million people around the world suffer from this condition, and it is classified as the second most serious neurological disease known to humanity, after stroke. With early and accurate detection of seizures, doctors can gain valuable time to administer medications and other such anti-seizure countermeasures to help reduce the damaging effects of this crippling disorder. The time-varying dynamics and high inter-individual variability make early prediction of the seizure state a challenging task. Many studies have shown that EEG signals do have valuable information that, if correctly analyzed, could help in the prediction of seizures in epileptic patients before their occurrence. Several mathematical transforms have been analyzed for its correlation with seizure onset prediction, and a series of experiments were done to certify their strengths. New algorithms are presented to help clarify, monitor, and cross-validate the classification of EEG signals to predict the ictal (i.e. seizure) states, specifically the preictal, interictal, and postictal states in the brain. These new methods show promising results in detecting the presence of a preictal phase prior to the ictal state.
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