对多种多重耐药革兰氏阴性菌具有良好的抗菌活性

Ozlem Oyardi, P. Savage, Alper Akçalı, Z. Erturan, C. Bozkurt-Guzel
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引用次数: 2

摘要

Ceragenins是治疗多重耐药微生物引起的感染的新型有希望的药物。由于粘菌素耐药性已成为一个世界性的问题,对新的治疗药物的需求一直在稳步增加。因此,本研究旨在研究阳离子类固醇抗生素cergenins (CSA-8、CSA-13、CSA-142和CSA-192)对土耳其革兰氏阴性多重耐药菌株的体外抗菌活性。采用微量肉汤稀释法对分离的肺炎克雷伯菌、莫氏摩根菌、铜绿假单胞菌和嗜麦芽窄养单胞菌进行了实验。除3株外,其余微生物均被鉴定为多重耐药。其中,CSA-13的MIC值为8 ~ 64µg/ml,效果最好。但CSA-8的抑菌活性不显著。总之,在存在多药(包括粘菌素)耐药微生物的情况下,皮草蛋白似乎是一个很好的抗微生物治疗候选者。
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Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria
DOI : 10.26650/IstanbulJPharm.2018.400730 Ceragenins are novel promising agents for the treatment of infections caused by multi-drug resistant microorganisms. Since colistin resistance has become a worldwide problem, the need for new treatment agents has been increasing steadily. Therefore, this study aimed to investigate in vitro antimicrobial activities of ceragenins (Cationic Steroid Antibiotics) (CSA-8, CSA-13, CSA-142 and CSA-192) against multidrug resistant Gram negative isolates from Turkey. Experiments were performed by using broth microdilution method against Klebsiella pneumoniae, Morganella morganii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia isolates. All microorganisms except for three isolates were identified as multidrug resistant. Among tested ceragenins, CSA-13 showed the best results (MIC: 8-64 µg/ml). Nevertheless, the antimicrobial activity of CSA-8 was not significant. In conclusion, ceragenins appear to be a good candidate as antimicrobial therapy in the presence of multidrug (including colistin) resistant microorganisms.
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