2型糖尿病首次诊断时定量微量白蛋白尿发生率的社区评估——kumbakonam城乡流行病学研究

IF 0.2 Q4 PHARMACOLOGY & PHARMACY Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2022-10-01 DOI:10.4103/ajprhc.ajprhc_101_22
M. Suchitra, M. Anand, B. Saravanan, S. Parthasarathy
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摘要

背景:糖尿病肾病(DN)是一种持续蛋白尿和进行性肾功能丧失的疾病,该术语意味着肾小球疾病的典型描述模式的发生。该疾病的早期标志是在尿液中检测微量白蛋白尿。方法:对首次诊断为糖尿病(DM)的患者进行抽样调查。前100名同意参与的成年患者被纳入研究。采用已建立的方法,从早晨的第一个样本中定量估计尿液中的微量白蛋白。所有正面的报道都遭到了反驳。开始用药是由医生来选择的。任何其他事件都被记录下来。到达时,随机记录血糖和血压。采用描述性分析和Pearson相关分析。结果:共分析101例患者。男性58人,女性43人。新诊断病例微量白蛋白尿阳性率为44.6%。随机血糖值、年龄或性别与微量白蛋白尿发生率之间没有关系。阳性和阴性病例的平均年龄相近。结论:在我们的研究中,新诊断的糖尿病患者中微量白蛋白尿的发生率较高。鉴于诊断时早期肾损害的发生率如此之高,我们建议初始治疗应从其他药物转向钠-葡萄糖共转运蛋白2 (SGLT2)抑制剂。我们推测,高发病率可能是由于我们地区糖尿病的诊断延迟和疾病控制不佳。由于诊断时早期肾损害的发生率如此之高,我们建议初始治疗应从其他药物转向SGLT2抑制剂。这是第一个关于首次诊断为糖尿病的早期肾病发生率的研究。
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Community assessment of incidence of quantitative microalbuminuria at the time of first diagnosis of type 2 diabetes mellitus – kumbakonam urban–rural epidemiological study – kures 9
Background: Diabetic nephropathy (DN) is a condition defined by persistent albuminuria and progressive loss of kidney function, with the term implying the occurrence of a typical described pattern of glomerular disorder. The early marker of the disease is detecting microalbuminuria in the urine. Methods: The patients who consented for the sampling was considered when they were diagnosed with diabetes mellitus (DM) for the first time. The first hundred adult patients who consented to participate were included. Established methods were used to estimate quantitative microalbumin in the urine from the first sample of the morning. All the positive reports were counter-checked. The initiation of drugs was left to the physician's choice. Any other events were recorded. On arrival, random blood sugar and blood pressures were recorded. Descriptive analyses and Pearson correlation analyses were used. Results: A total of 101 patients were analyzed. There were 58 males and 43 females. The microalbuminuria was positive in 44.6% of newly diagnosed cases. There was no relationship between the random sugar values, age, or sex with the incidence of microalbuminuria. The mean ages of both the positive and negative cases were similar. Conclusion: There was a high incidence of microalbuminuria in our study among newly diagnosed DM. With such a high incidence of early renal damage on diagnosis, we suggest that the initial management should switch from other drugs to inhibitors of the sodium-glucose cotransporter 2 (SGLT2). We theorize that the high incidence may be due to a delayed diagnosis of diabetes in our area and a poor control of the disease. With such a high incidence of early renal damage on diagnosis, we suggest that the initial management should switch from other drugs to inhibitors of the SGLT2. This is the first such study on the incidence of early nephropathy on first diagnosis of DM.
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