不同提取方法对虎尾草甲醇提取物抗氧化及毒性活性的影响

Riong seulina Panjaitan, Windri Yuliana
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引用次数: 1

摘要

在西爪哇加鲁特的Sayang Heulang海滩采集到红藻。它有许多次生代谢物,可能作为天然抗氧化剂的来源。本研究的目的是比较在特定的时间变化条件下,粗草甲醇提取物的最佳提取方法,以获得最高的收率、抗氧化活性和毒性。本研究采用实验方法,包括大型藻类的取样和制备、植物化学筛选、浸渍法和UAE法提取细叶藻、基于DPPH (2.2 diphenyl-1-picrylhydrazyl)的抗氧化活性测试和基于BSLT(盐水虾致死)法的毒性测试。结果表明,黄精甲醇提取物中含有黄酮类化合物和甾类化合物,浸提得率为12.93%,UAE得率为12.1%。浸渍处理的抗氧化活性(IC50)为86.46 ppm, UAE处理的IC50为59.01 ppm。浸渍的毒性试验LC50为28.35 ppm, UAE为27.76 ppm。从其IC50值来看,浸渍甲醇提取物和凤尾花具有成为强效抗氧化剂的潜力。然后,浸渍甲醇提取物和阿联酋被列入剧毒类别。
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ANTIOXIDANT AND TOXICITY ACTIVITIES of Gracilaria gracilis METHANOL EXTRACT BASED ON DIFFERENT EXTRACTION METHODS
Gracilaria gracilis (red macroalgae) was collected from Sayang Heulang Beach, Garut, West Java. It has a number of secondary metabolites that potentially serve as a source of natural antioxidants. The objective of this study was to compare the optimal extraction method in particular time variation for producing the highest percent of yield, antioxidant activity, and toxicity of G. gracilis methanol extract. This study was conducted experimentally, including macroalgae sampling and preparation, phytochemical screening, extraction of G. gracilis by maceration and UAE methods, antioxidant activity testing based on the DPPH test (2.2 diphenyl-1-picrylhydrazyl) and toxicity testing using the BSLT (Brine Shrimp Lethality) method. The results indicated that the methanol extract of G. gracilis contains flavonoids and steroids, with yield percentages of 12.93% for maceration and 12.1% for UAE. The antioxidant activity (IC50) of maceration was 86.46 ppm, whereas the UAE was 59.01 ppm. Then, the toxicity test (LC50) for maceration was 28.35 ppm whereas the UAE was 27.76 ppm. Macerated methanol extract and UAE G. gracilis have the potential to be powerful antioxidants based on their IC50 values. Then, macerated methanol extract and UAE are included in the highly toxic category.
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