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Pemanfaatan Lumpur Lapindo sebagai Sumber Silika Magnetik untuk Adsorpsi Tumpahan Crude Palm Oil 利用拉平多泥作为原油棕榈油泄漏吸附的磁性二氧化硅来源
Pub Date : 2024-04-23 DOI: 10.25077/jrk.v15i1.658
Wihda Zuhara, Rahmad Nuryanto, R. A. Lusiana, Lisna Efiyanti
In this paper, synthesis of silica magnetite adsorbent has been carried out from Lapindo Mud silica and magnetite (Fe3O4) using the template Cetyltrimethylammonium bromide (CTAB) through a microemulsion process. This research aims to determine the adsorption ability of magnetic silica material as an adsorbent for Crude Palm Oil (CPO) with varying contact times of 10, 20, 30, 60, 90 minutes and an adsorbate concentration of 0,2, 0,4, 0,6, 0,8 and 1 gram. Silica is obtained from Lapindo Mud extraction using the acid leaching method using HCl. Magnetite was prepared by mixing ferric chloride and ferrous chloride salts with an alkaline base. Synthesis of magnetic silica adsorbent using CTAB and 1-butanol as a surfactant and co-surfactant, respectively. The characterization results from FTIR and SEM-EDX data identified the presence of silanol (Si-OH) and Fe-O groups, magnetic silica adsorbent showed an irregular morphological pattern, the size tended to be heterogeneous, contained Fe, O and Si elements. The XRD results show that there are peaks in the (200), (311) and (440) planes, the GSA results show that the pore surface area is 37.048 m2/g, the total pore volume is 0.321 cm3/g and the pore diameter is 33.907 nm, which indicates that the pores have a mesoporous structure. Based on this research, the optimum contact time is 60 minutes with adsorption kinetics following the pseudo-second order and Langmuir isotherm with an adsorption capacity of 1.76 mg/g.
本文使用十六烷基三甲基溴化铵(CTAB)为模板,通过微乳化工艺,从 Lapindo 泥二氧化硅和磁铁矿(Fe3O4)中合成了二氧化硅磁铁矿吸附剂。本研究旨在确定磁性二氧化硅材料作为粗棕榈油(CPO)吸附剂的吸附能力,吸附剂的接触时间分别为 10、20、30、60 和 90 分钟,吸附浓度分别为 0.2、0.4、0.6、0.8 和 1 克。白炭黑是用盐酸酸浸法从拉平多泥中提取的。磁铁矿由氯化铁盐和氯化亚铁盐与碱性碱混合制备而成。使用 CTAB 和 1-丁醇分别作为表面活性剂和辅助表面活性剂合成磁性二氧化硅吸附剂。傅立叶变换红外光谱和扫描电镜-电子显微镜数据的表征结果确定了硅醇(Si-OH)和 Fe-O 基团的存在,磁性二氧化硅吸附剂呈现出不规则的形态图案,大小趋于异构,含有 Fe、O 和 Si 元素。XRD 结果表明,在(200)、(311)和(440)面上存在峰值,GSA 结果表明,孔表面积为 37.048 m2/g,总孔体积为 0.321 cm3/g,孔直径为 33.907 nm,这表明孔具有介孔结构。根据这项研究,最佳接触时间为 60 分钟,吸附动力学遵循假二阶和 Langmuir 等温线,吸附容量为 1.76 mg/g。
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引用次数: 0
Pemanfaatan Ekstrak Daun Sirih Hijau (Piper Betle Linn.) sebagai Capping Agent dalam Green Synthesis Spinel Ferit ZnFe2O4 untuk Remediasi Fenol dalam Air dan sebagai Anti Bakteri 利用绿槟榔叶提取物(Piper Betle Linn.)
Pub Date : 2024-04-23 DOI: 10.25077/jrk.v15i1.685
Rahmayeni Rahmayeni, Putri Yuliani, Yuliati Eka Putri, Yeni Stiadi
The spinel ferrite material ZnFe2O4 was synthesized using a green synthesis approach by the hydrothermal method. In the synthesis, 2M NaOH was used as a mineralizer and betel leaf extract with varying volumes of 1, 3, 5, and 7 mL as a capping agent, then continued with calcination at 500, 600, and 700°C. Several devices, such as XRD, FT-IR, SEM-EDX, DRS-UV-Vis, and VSM, were used to characterize the synthesized ZnFe2O4 material. The pattern of XRD indicated that the ZnFe2O4 material has a cubic structure, where the increase in crystal size was after calcination. The Fourier Transform Infra-Red (FT-IR) spectrum shows the Fe-O interaction at wave numbers 427-417 cm-1, which is located on the octahedral side, while the Zn-O interaction at wave numbers 534-510 cm-1, which is located on the tetrahedral side in spinel ferrite structure. From the DRS UV-Vis spectrum pattern and band gap values, it was found that the material absorbs light in the visible region. Scanning Electron Microscope (SEM) images show that the morphology of the synthesized material is circular. The Vibrating Sample Magnetometer (VSM) hysteresis curve shows that the synthesized ZnFe2O4 has paramagnetic properties. The synthesized ZnFe2O4 material has photocatalytic activity towards phenolic compounds with a degradation percentage reaching 62.2%, and this material is active as an antibacterial with an inhibition area of 14.4 for S. aereus bacteria.
通过水热法,采用绿色合成方法合成了尖晶石铁氧体材料 ZnFe2O4。在合成过程中,以 2M NaOH 作为矿化剂,以 1、3、5 和 7 mL 不同体积的槟榔叶提取物作为封端剂,然后继续在 500、600 和 700°C 煅烧。利用 XRD、FT-IR、SEM-EDX、DRS-UV-Vis 和 VSM 等设备对合成的 ZnFe2O4 材料进行了表征。XRD 图谱表明,ZnFe2O4 材料具有立方结构,晶体尺寸在煅烧后增大。傅立叶变换红外光谱(FT-IR)显示,在尖晶石铁氧体结构中,Fe-O 相互作用的波数为 427-417 cm-1,位于八面体一侧,而 Zn-O 相互作用的波数为 534-510 cm-1,位于四面体一侧。从 DRS 紫外可见光谱图和带隙值可以发现,该材料在可见光区域吸收光。扫描电子显微镜(SEM)图像显示,合成材料的形态为圆形。振动样品磁力计(VSM)磁滞曲线显示,合成的 ZnFe2O4 具有顺磁特性。合成的 ZnFe2O4 材料对酚类化合物具有光催化活性,降解率达到 62.2%,而且这种材料还具有抗菌活性,对 S. aereus 细菌的抑制面积为 14.4。
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引用次数: 0
Karakterisasi Struktur Kumarin pada Akar Tumbuhan Langsat (Lansium domesticum Corr.) 兰萨特植物根(Lansium domesticum Corr.)
Pub Date : 2024-04-23 DOI: 10.25077/jrk.v15i1.610
Riska Nurapita, Rudiyansyah, Harlia
Lansium plants produce not only terpenoids as the main constituent but also contain phenolics on the basis of phytochemical analysis. Unfortunately, there are still limited information about phenolic structures from this plants. This study was conducted to identify one of phenolic structures from chloroform fraction of Lansium domesticum root. The chloroform fraction was fractionated and purified by chromatographic techniques such as vacuum liquid chromatography (VLC) and column chromatography (CC) to obtain a coumarin. Additionally, the coumarin structure was characterized by 1H-NMR. The isolated coumarin showed a positive result for the phenolic test with FeCl3 5%. The 1H-NMR spectrum of isolated coumarin revealed chemical shifts at δH 7,60 (1H, d, J = 9,5 Hz), 6,92 (1H, s), 6,84 (1H, s), 6,27 (1H, d, J = 9,5 Hz), 6,14 (1H, s), and 3,95 (3H, s). Based on those results and comparison with literature data, it can be concluded that the isolated coumarin is iso-scopoletin (1)
根据植物化学分析,兰西植物不仅以萜类化合物为主要成分,还含有酚类物质。遗憾的是,有关这种植物酚类结构的信息仍然有限。本研究旨在从 Lansium domesticum 根的氯仿馏分中鉴定一种酚类结构。通过真空液相色谱法(VLC)和柱色谱法(CC)等色谱技术对氯仿馏分进行分馏和纯化,获得了一种香豆素。此外,还利用 1H-NMR 对香豆素的结构进行了表征。分离出的香豆素在 5%氯化铁的酚类测试中呈阳性结果。分离出的香豆素的 1H-NMR 光谱显示化学位移为 δH 7,60 (1H, d, J = 9,5 Hz)、6,92 (1H, s)、6,84 (1H, s)、6,27 (1H, d, J = 9,5 Hz)、6,14 (1H, s) 和 3,95 (3H, s)。根据这些结果以及与文献数据的比较,可以得出结论:分离出的香豆素是异香豆素 (1)
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引用次数: 0
Polypeptide Antibiotic Produced by a Thermo-Halophilic Bacterium from Pria Laot Sabang 76 Isolate 来自 Pria Laot Sabang 76 分离物的嗜热嗜热细菌产生的多肽抗生素
Pub Date : 2024-04-23 DOI: 10.25077/jrk.v15i1.634
Febriani Febriani, M. A. Suzanni, Ellenia Rakashiwi, Nurdin, T. Iqbalsyah
Extremophiles are known to produce antibiotics. This study aimed to isolate and purify polypeptide antibiotics from Pria Laot Sabang (PLS) 76, a bacterium isolated from an undersea fumarole. The antibiotic production was done by cultivating PLS 76 in a 2.5% TSB liquid medium and incubated at 70°C, 150 rpm for 112 hours. Ninhydrin assay on the crude supernatant after centrifugation indicated that the PLS 76 produced a polypeptide antibiotic. The supernatant was partitioned using methanol. The antibiotic activity was tested using the Kirby-Bauer method, and the inhibition zone was about 12 mm against Escherichia coli and Staphylococcus aureus. The methanol fraction was purified further by Preparative Thin Layer Chromatography and produced several fractions. Fractions with the same Rf were pooled and subjected to the ninhydrin assay. Fraction A, which gave a positive result after the ninhydrin assay, showed an inhibition zone of only 7 mm against E. coli and S. aureus. The Quadrupole Time-of-Flight (QTOF) Mass Spectrometry data indicated that the antibiotic's structure was similar to Polymyxin B2, an antibiotic of a polypeptide group.
众所周知,嗜极细菌能产生抗生素。本研究旨在从从海底火口分离出来的细菌 Pria Laot Sabang (PLS) 76 中分离和纯化多肽抗生素。在 2.5% TSB 液体培养基中培养 PLS 76,并在 70°C、150 转/分的条件下培养 112 小时,从而生产出抗生素。对离心后的粗上清液进行茚三酮检测,结果表明 PLS 76 产生了一种多肽抗生素。上清液用甲醇分馏。用 Kirby-Bauer 法检测抗生素活性,结果表明 PLS 76 对大肠杆菌和金黄色葡萄球菌的抑菌区约为 12 毫米。甲醇馏分经制备型薄层色谱法进一步纯化,产生了多个馏分。将具有相同 Rf 的馏分集中起来,进行茚三酮检测。经茚三酮检测呈阳性结果的馏分 A 对大肠杆菌和金黄色葡萄球菌的抑制区仅为 7 毫米。四极杆飞行时间质谱(QTOF)数据表明,该抗生素的结构与多肽类抗生素多粘菌素 B2 相似。
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引用次数: 0
A New Insight Into Toxicity of Database Compounds from Ginger (Zingiber officinale) by Modelling Study 通过建模研究对生姜数据库化合物毒性的新认识
Pub Date : 2024-04-23 DOI: 10.25077/jrk.v15i1.638
N. Frimayanti, Mira Febrina, Annisa Yuri Amalia
Dengue haemorrhagic fever (DHF) is an infectious disease caused by the dengue virus. The dengue virus is transmitted through female mosquitoes, especially Aedes aegypti and Aedes albopictus. Indonesia is a dengue endemic country, and almost all provinces in Indonesia are infected with dengue. However, targeted antiviral drugs against dengue virus (DENV) are not yet available. This study aimed to determine the potential of three compounds isolated from ginger (Zingiber officinale) as dengue NS2B/NS3 inhibitors, and to predict the physicochemical properties (drug-likeness) and potential toxicity of drug candidates. Ginger isolates in the form of [8]-gingerol, [6]-paradol, shogaol were obtained from the Natural Discovery Database (NADI). Toxicity and drug-likeness predictions were performed using ProTox-II and SwissADME, and Molecular Operating Environment (MOE) 2022.0901 was used for the molecular docking process. Results: The results showed that the ginger compound (Zingiber officinale), [8]-Gingerol, [6]-Paradol, and Shogaol, had binding free energy of -7.18, -7.10 and -6.88 kcal/mol, respectively. It is indicated that three compounds had  potentiality to inhibit the NS2B/NS3 protein complex with a binding free energy that was almost equivalent to that of the positive control, panduratin A, and similar to that of the positive control, which can be seen in superimposition. In addition, three compounds isolated from ginger met the drug-likeness parameters. Based on the analysis of in silico toxicity studies, the three compounds isolated from ginger showed different levels of toxicity. Therefore, based on the safety level of oral use, the [8]-gingerol compound is safer to develop as a dengue antiviral drug, where the LD50 value of [8]-gingerol is 2.580 mg/kg with a class V toxicity level that is practically nontoxic.
登革出血热(DHF)是一种由登革病毒引起的传染病。登革热病毒通过雌蚊传播,尤其是埃及伊蚊和白纹伊蚊。印度尼西亚是登革热流行国家,几乎所有省份都感染了登革热。然而,目前还没有针对登革热病毒(DENV)的靶向抗病毒药物。本研究旨在确定从生姜(Zingiber officinale)中分离出的三种化合物作为登革热 NS2B/NS3 抑制剂的潜力,并预测候选药物的理化性质(药物相似性)和潜在毒性。研究人员从自然发现数据库(NADI)中获得了[8]-姜酚、[6]-paradol和shogaol形式的生姜分离物。使用 ProTox-II 和 SwissADME 进行毒性和药物相似性预测,并使用分子操作环境(MOE)2022.0901 进行分子对接。结果表明结果表明,生姜化合物(Zingiber officinale)、[8]-Gingerol、[6]-Paradol 和 Shogaol 的结合自由能分别为 -7.18、-7.10 和 -6.88 kcal/mol。这表明,这三种化合物具有抑制 NS2B/NS3 蛋白复合物的潜力,其结合自由能与阳性对照 panduratin A 几乎相当,与阳性对照相似,这可以从叠加中看出。此外,从生姜中分离出的三种化合物符合药物相似性参数。根据硅学毒性研究分析,从生姜中分离出的三种化合物表现出不同程度的毒性。因此,根据口服使用的安全等级,[8]-姜酚化合物作为登革热抗病毒药物开发更为安全,其中[8]-姜酚的半数致死剂量为 2.580 毫克/千克,毒性等级为 V 级,几乎无毒。
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引用次数: 0
Senyawa Isoflavonoid dari Akar Gitaan (Willughbeia coriacea Wall.) 来自吉它根(Willughbeia coriacea Wall.)的异黄酮类化合物
Pub Date : 2024-04-23 DOI: 10.25077/jrk.v15i1.686
Jamarlia Aprenesya, Puji Ardiningsih., dan Rudiyansyah
Gitaan (Willughbeia coriacea Wall.) is an endemic plant that grows wild in the forests of Kalimantan. Traditionally, parts of this plant have been applied for fork-lore medication in Dayak tribe. However, scarce information both for secondary metabolites and biological activities of this plant has been reported, especially for flavonoids. This research was conducted to determine structure of flavonoid from ethyl acetate fraction of gitaan roots by spectroscopy analysis. The ethyl acetate fraction was purified by several chromatography techiques in order to isolate compound 1. On the basis of NMR analysis including DART-HRMS data and comparison with literature, an isoflavonoid obtained from the ethyl acetate fraction of gitaan roots is formononetin.
Gitaan(Willughbeia coriacea Wall.)是一种生长在加里曼丹森林中的野生特有植物。传统上,达雅克(Dayak)部落将这种植物的部分成分用于叉叉药。然而,关于这种植物的次生代谢物和生物活性,尤其是黄酮类化合物的信息报道很少。本研究通过光谱分析确定了吉塔安根乙酸乙酯馏分中黄酮类化合物的结构。根据核磁共振分析(包括 DART-HRMS 数据)以及与文献的比较,从 gitaan 根的乙酸乙酯馏分中获得的异黄酮类化合物是福莫尼定。
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引用次数: 0
Minyak Atsiri Serai Wangi (Cymbopogon nardus L. Rendle): Diisolasi dengan Dua Metode Berbeda, Kualitas dan Aktivitas Antibakterinya 香茅精油(Cymbopogon nardus L. Rendle):用两种不同方法分离出的香茅精油及其质量和抗菌活性
Pub Date : 2024-04-23 DOI: 10.25077/jrk.v15i1.653
Afrizal, Anggun Defitriani, Mai Efdi
Cymbopogon nardus L. Rendle is one of the world trades essential oil plants. The high selling value of citronella oil is determined by the characteristics of its physical and chemical properties. In this study, determined the physical and chemical properties of citronellal oil isolated by two different methods, namely method of laboratory distillation (M1) and local community distillation (M2). The result showed that the essential oil produce from both methods match with SNI 06-3953-1995 on its physical properties. The results of the chemical composition using Gas Chromatography-Mass Spectrometry (GC-MS) indicated there are 38 and 48 compounds in the essential oil of M1 and M2, respectively with the main compositions are citronellal, citronellol, and geraniol. The antibacterial activity evaluated using the disc diffusion method showed inhibitory ability against the growth of Staphylococcus aureus and Staphylococcus epidermidis, but no inhibitory ability of Pseudomonas aeruginosa. Both, these M1 and M2 essential oils are categorized as a very strong antibacterial at concentration of 3.125% and 50%, respectively.
香茅(Cymbopogon nardus L. Rendle)是世界上畅销的精油植物之一。香茅油的高销售价值取决于其物理和化学特性。在这项研究中,通过两种不同的方法,即实验室蒸馏法(M1)和当地社区蒸馏法(M2),测定了分离出来的香茅油的物理和化学特性。结果表明,两种方法分离出的香茅精油的物理特性均符合 SNI 06-3953-1995。使用气相色谱-质谱法(GC-MS)检测化学成分的结果表明,M1 和 M2 的精油中分别含有 38 和 48 种化合物,主要成分为香茅醛、香茅醇和香叶醇。采用盘扩散法评估的抗菌活性表明,它们对金黄色葡萄球菌和表皮葡萄球菌的生长具有抑制能力,但对铜绿假单胞菌没有抑制能力。M1 和 M2 精油的浓度分别为 3.125% 和 50%,都被归类为极强抗菌剂。
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引用次数: 0
Efektifitas Reaksi Transesterifikasi Minyak Kelapa dan Sereh untuk Pembuatan Perisa Alami dengan Biokatalisator Lipase serta Penggunaan Ultrasonik 利用脂肪酶生物催化剂和超声波进行椰子油和香茅油酯交换反应制备天然香精的有效性
Pub Date : 2024-04-23 DOI: 10.25077/jrk.v15i1.641
Dwina Moentamaria, N. Rizki, Rosita Dwi Chrisnandari, Zakijah Irfin, Dyah Ratna Wulan
In general, flavor are synthesis through enzymatic hydrolysis and esterification reactions (up to 20 hours) using commercial ingredients based on free fatty acids and alcohol. Efficient endeavors utilizing enzymatic transesterification to expedite reactions are necessary to acquire flavored products. Substrates may originate from commercial or natural sources abundant in fatty acids and alcohol. Commercial fatty acids and alcohol (geraniol) are readily available in pure forms. Alternatively, fatty acids can be sourced from coconut oil, while geraniol can be derived from lemongrass oil, which is more cost-effective compared to commercial ingredients. Ultrasonics have emerged as a means to expedite enzymatic. The objective of this study is to investigate the impact of ultrasonic power and transesterification reaction time between coconut oil and geraniol on geraniol conversion. Utilizing lipase (415.99 U/g), coconut oil was subjected to transesterification with commercially obtained pure geraniol in a 1:3 weight ratio, conducted in an ultrasonic tank filled with water. Reaction durations spanned 30, 60, 90, 120, and 150 minutes, with ultrasonic powers set at 50, 70, and 90 watts. The study findings elucidated that the highest geraniol conversion rate of 50.59% was achieved with 70 watts of ultrasonic power over a 90-minute period. These optimal conditions were subsequently applied to transesterify coconut oil with geraniol from lemongrass oil, yielding a conversion rate of 90.29%. This finding demonsttrate the posibility of employing coconut oil and lemongrass oil in a one-stage transesterification process to produce natural flavors via enzymatic lipase catalysis expedited by ultrasonic technology, facilitating swift reaction times.
一般来说,香料是通过酶水解和酯化反应(长达 20 个小时),使用以游离脂肪酸和酒精为基础的商业成分合成的。要获得香精产品,就必须有效地利用酶促酯交换反应来加快反应速度。底物可以来自富含脂肪酸和酒精的商业或天然来源。商品脂肪酸和醇(香叶醇)的纯度很高。另外,脂肪酸可以从椰子油中提取,而香叶醇可以从柠檬草油中提取,后者与商业成分相比更具成本效益。超声波已成为加速酶解的一种手段。本研究旨在探讨椰子油和香叶醇之间的超声波功率和酯交换反应时间对香叶醇转化的影响。利用脂肪酶(415.99 U/g),椰子油与从市场上获得的纯香叶醇以 1:3 的重量比进行酯交换反应,反应在充满水的超声波罐中进行。反应时间分别为 30、60、90、120 和 150 分钟,超声波功率分别为 50、70 和 90 瓦。研究结果表明,在 90 分钟的时间内,超声波功率为 70 瓦时,香叶醇的转化率最高,达到 50.59%。随后,将这些最佳条件用于从柠檬草油中提取的香叶醇对椰子油进行酯交换,转化率达到 90.29%。这一发现表明,椰子油和香茅油可以在一个阶段的酯交换过程中,通过超声波技术加速酶脂肪酶催化反应来生产天然香料,从而缩短反应时间。
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引用次数: 0
The Density Functional Tight Binding (DFTB) Approach for Investigating Vacancy and Doping in Graphene as Hydrogen Storage 密度泛函紧密结合 (DFTB) 法研究石墨烯中的空位和掺杂储氢
Pub Date : 2024-04-23 DOI: 10.25077/jrk.v15i1.635
Y. Hidayat, Fitria Rahmawati, Khoirina Dwi Nugrahaningtyas, Paulus Bagus Swandito
A study on graphene defects for hydrogen storage has been successfully conducted using the Density Functional Tight Binding (DFTB) approach. The research aimed to modify solid materials for hydrogen storage. A 4 × 4 × 1 unit cell was used as the basis, while the supercell used for sampling was enlarged to 40 × 40 × 1. The analyzed data included changes in Density of States (DOS), Fermi level shifts, electronic band structures, formation energy, adsorption energy, and isosurfaces for each graphene orientation. It has been observed that modifying the surface structure of graphene can alter the electronic properties of graphene. This is indicated by shifts in DOS intensity, characterized by increased electronic intensity around the Fermi level total density charge different. The interaction energy between graphene and hydrogen gas has been determined to be -0.0155 eV for H-epoxy graphene, -0.4941 eV for H-monovacancy graphene, and -0.0424 eV for HN-monovacancy graphene. The presence of the vacancy increase the potential to adsorp hydrogen.
利用密度泛函紧密结合(DFTB)方法,成功开展了一项有关用于储氢的石墨烯缺陷的研究。该研究旨在改造固体材料以实现储氢。分析数据包括石墨烯各取向的状态密度(DOS)、费米级移动、电子带结构、形成能、吸附能和等表面的变化。据观察,改变石墨烯的表面结构可以改变石墨烯的电子特性。这表现在 DOS 强度的变化上,其特点是费米级附近的电子强度增加,总密度电荷不同。经测定,H-环氧石墨烯与氢气之间的相互作用能为-0.0155 eV,H-单质石墨烯为-0.4941 eV,HN-单质石墨烯为-0.0424 eV。空位的存在增加了吸附氢的潜力。
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引用次数: 0
Cytotoxic Potential of Compounds Isolated from Non-Polar Fractions of Sungkai Plant Leaves (Peronema canescens Jack) Against Artemia salina Leach Larvae 从宋开植物叶(Peronema canescens Jack)非极性馏分中分离出的化合物对鲑鳟幼虫的细胞毒性潜力
Pub Date : 2024-04-23 DOI: 10.25077/jrk.v15i1.655
Suryati, Irfan Afrinal, Afrizal, Rahmi Vika, Ulia
The sungkai plant (Peronema canescens Jack), belonging to the Lamiaceae family, is a plant that is traditionally used as medicine, including toothache, malaria, and fever medicine. In this research, isolation was carried out with vacuum liquid chromatography (VLC), solid and liquid fractions were obtained. The solid fraction was further separated using column chromatography to obtain the isolated compound as a white solid (amorphous) weighing 10 mg (melting point 140˚C-142˚C). The results of the UV spectrum data show that there are no conjugated double bonds. The results of the IR spectrum show the presence of C-H groups at wave numbers 2921,49 cm-1 and 2856,94 cm-1, C=O groups at wave numbers, C=C groups at wave numbers 1641,51 cm-1, and dimethyl germinal which is characteristic of triterpenoid compounds at wave numbers 1456.68 cm-1 and 1372.41 cm-1. Meanwhile, the isolated oil was analyzed for chemical components using GC-MS. It was discovered that there were 83 chemical compound components contained therein with 4 main compound components, namely pentadecanoic acid (16.65%), 9,12-octadecanoic acid (16.12%), propyl palmitate (7.89%), and hexadecenoic acid, methyl ester (5.59%). A cytotoxic test was carried out on both fractions using the Brine Shrimp Lethality Test (BSLT) method. The results showed that the isolated compound was non-toxic with an LC50 value of 190214.2807 mg/L and the isolated oil was very toxic with an LC50 value of 34.2452 mg/L.
宋凯植物(Peronema canescens Jack)属于唇形科,是一种传统的药用植物,包括牙痛、疟疾和发烧药。本研究采用真空液相色谱法(VLC)进行分离,得到固态和液态馏分。固体馏分经柱层析进一步分离,分离出的化合物为白色固体(无定形),重 10 毫克(熔点 140˚C-142˚C)。紫外光谱数据结果表明,该化合物不存在共轭双键。红外光谱结果表明,在波数为 2921,49 cm-1 和 2856,94 cm-1 的位置存在 C-H 基团,在波数为 1641,51 cm-1 的位置存在 C=O 基团,在波数为 1456.68 cm-1 和 1372.41 cm-1 的位置存在三萜类化合物特有的二甲基芽基。同时,利用气相色谱-质谱对分离出的油进行了化学成分分析。结果发现,其中含有 83 种化合物成分,主要有 4 种化合物成分,即十五烷酸(16.65%)、9,12-十八烷酸(16.12%)、棕榈酸丙酯(7.89%)和十六烯酸甲酯(5.59%)。采用盐水虾致死试验(BSLT)方法对这两种馏分进行了细胞毒性试验。结果表明,分离出的化合物无毒,半数致死浓度为 190214.2807 毫克/升,而分离出的油类有剧毒,半数致死浓度为 34.2452 毫克/升。
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