亲和力增强T细胞是HIV治疗的未来吗?

HIV therapy Pub Date : 2009-03-06 DOI:10.2217/17584310.3.2.105

B. Jakobsen, A. Sewell, C. June

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引用次数: 1

摘要

这表明在极少数情况下，HIV-1感染可以通过保护性t细胞反应得到有效控制。利用淋巴细胞性绒毛膜脑膜炎病毒(LCMV)模型对t细胞衰竭进行了最彻底的研究。小鼠迅速清除野生型LCMV感染并产生保护性记忆。相比之下，LCMV的两个氨基酸取代突变体(克隆13)不能被清除，从而导致慢性、持续性感染

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Are affinity-enhanced T cells the future of HIV therapy?

, suggesting that under rare circumstances HIV-1 infection can be effectively controlled by a protective T-cell response.T-cell exhaustion has been most thoroughly studied using the lymphocytic choriomenin-gitis virus (LCMV) model. Mice clear wild-type LCMV infection rapidly and protective memory develops. By contrast, a two amino-acid substitu-tion mutant of LCMV (Clone 13) is not cleared and a chronic, persistent infection ensues

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HIV therapy

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