J. Heughebaert, A. Lebugle, F. Vu, R. Phan-tan-luu
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Central composite design and optimization by multiresponse analysis of octacalcium phosphate synthesis
Synthesis of octacalcium phosphate (OCP) by hydrolysis of brushite was studied using a 3 block central composite design including 4 factors and 6 responses. Analysis of the responses allowed the definition of one set of experimental conditions in which OCP was obtained with the highest overall desirability (87.6 %).
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