Hematopoietic stem cell transplantation for Ph-like acute lymphoblastic leukemia and literature review

Objective To explore the efficacy of hematopoietic stem cell transplantation (HSCT) for 5 patients with Ph-like acute lymphoblastic leukemia (ALL). Methods Fluorescent in situ hybridization (FISH) was performed for detecting the rearrangement of susceptibility genes. Combined therapy of chemotherapy and ruxolitinib were applied, followed by HSCT. Those failing to achieve complete remission (CR) received an infusion of chimeric antigen T-cells (CAR-T), followed by HSCT once CR was achieved. Four patients accept allogenic HSCT while another auto HSCT. Results Three of them achieved CR after chemotherapy and ruxolitinib. The remaining 2 patients got CR after CAR-T. Four patients remained in CR after HSCT. Early relapse occurred in 1 patient after HSCT. Conclusions Combined therapy of chemotherapy, ruxolitinib and CAR-T are necessary for Ph-like ALL patients. HSCT after an initial CR improve patient prognosis. Key words: Heamatopoietic stem cell transplantation; Lymphoblastic leukemia; Acute