{"title":"细胞外光敏反应损伤机理及其应用","authors":"E. Ogawa, T. Arai, H. Kumagai","doi":"10.2530/JSLSM.JSLSM-41_0037","DOIUrl":null,"url":null,"abstract":"Extracellular photosensitization reaction produces singlet oxygen outside the cell with a high concentration of the photosensitizer distributed outside the cell by short drug-light interval. The extracellularly generated singlet oxygen allows for the immediate damage effects of cell membrane and ion channel damage. In this review, the damage mechanism caused by extracellular photosensitization will be explained, with a focus on the application of the extracellular photosensitization reaction using talaporfin sodium for the treatment of tachyarrhythmia catheter ablation.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"5 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mechanism of Damage by Extracellular Photosensitization Reaction and Its Application\",\"authors\":\"E. Ogawa, T. Arai, H. Kumagai\",\"doi\":\"10.2530/JSLSM.JSLSM-41_0037\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Extracellular photosensitization reaction produces singlet oxygen outside the cell with a high concentration of the photosensitizer distributed outside the cell by short drug-light interval. The extracellularly generated singlet oxygen allows for the immediate damage effects of cell membrane and ion channel damage. In this review, the damage mechanism caused by extracellular photosensitization will be explained, with a focus on the application of the extracellular photosensitization reaction using talaporfin sodium for the treatment of tachyarrhythmia catheter ablation.\",\"PeriodicalId\":19350,\"journal\":{\"name\":\"Nippon Laser Igakkaishi\",\"volume\":\"5 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nippon Laser Igakkaishi\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2530/JSLSM.JSLSM-41_0037\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nippon Laser Igakkaishi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2530/JSLSM.JSLSM-41_0037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mechanism of Damage by Extracellular Photosensitization Reaction and Its Application
Extracellular photosensitization reaction produces singlet oxygen outside the cell with a high concentration of the photosensitizer distributed outside the cell by short drug-light interval. The extracellularly generated singlet oxygen allows for the immediate damage effects of cell membrane and ion channel damage. In this review, the damage mechanism caused by extracellular photosensitization will be explained, with a focus on the application of the extracellular photosensitization reaction using talaporfin sodium for the treatment of tachyarrhythmia catheter ablation.
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