不同年龄组正常范围甲状腺激素与冠状动脉疾病的关系

IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY International Journal of Gerontology Pub Date : 2021-07-01 DOI:10.6890/IJGE.202107_15(3).0016
YuJiao Sun, Jinyang Li, Ling Chen, Shijie Zhao, Liye Shi, Haiyan Zhang, W. Tian, G. Qi
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引用次数: 1

摘要

背景:甲状腺激素随年龄的变化可能部分解释年龄对冠状动脉疾病(CAD)的影响。然而,正常范围内甲状腺激素对不同年龄冠心病的影响尚不清楚。目的:探讨不同年龄组正常范围甲状腺激素水平与冠心病的关系。方法:769人入组。按年龄分为< 60岁和≥60岁两组。比较冠心病组和非冠心病组游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺激素(TSH)水平。采用logistic回归分析评价不同年龄组FT3、FT4、TSH与冠心病的相关性。结果:冠心病组总FT4水平显著高于非冠心病组(13.75±2.46∶12.90±1.58 pmol/l, p = 0.003)和≥60Y组(13.83±2.73∶12.69±1.47 pmol/l, p = 0.041)。冠心病的发病率在第4四分位数明显高于FT4的第1四分位数(7.2%比2.1%,p = 0.017)和≥60Y(14.5%比4.3%,p = 0.041)。单因素和多因素分析显示,ft4是60岁及以上人群CAD的独立危险因素(均p < 0.05)。在不同年龄组中,FT3、TSH和CAD之间没有关联。结论:FT4在正常范围内与60岁及以上人群的CAD相关,但FT3和TSH无关。FT4在正常范围内与CAD的关系可能受年龄的影响。
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Relationships of Thyroid Hormones in the Normal Range to Coronary Artery Disease in Different Age Groups
Background: The change of thyroid hormones with age may partially explain the effect of age on coronary artery disease (CAD). However, the effects of thyroid hormones within the normal range on CAD in different age were unkown. Aims: To evaluate the relationships between thyroid hormones within the normal range and CAD in different age groups. Methods: 769 individuals were enrolled. Individuals were divided into two groups according to their age: < 60 years and ≥ 60 years. Free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH)were compared between CAD and non-CAD group. The associations of FT3, FT4 and TSH with CAD in different age groups were evaluated by logistic regression analyses. Results: The levels of FT4 were significantly higher in CAD than non-CAD group of total (13.75 ± 2.46 vs. 12.90 ± 1.58 pmol/l, p = 0.003) and ≥ 60Y (13.83 ± 2.73 vs. 12.69 ± 1.47 pmol/l, p = 0.041). The incidences of CAD were significantly higher in the fourth quartile than the first quartile of FT4 in total (7.2% vs. 2.1%, p = 0.017) and ≥ 60Y (14.5% vs. 4.3%, p = 0.041). FT4was the independent risk factor for CAD in ≥ 60Y and total people by univariate and multivariate analyses (all p < 0.05). No associations were found between FT3, TSH and CAD in different age groups. Conclusions: FT4 within the normal range was associated with CAD in ≥ 60Y and total people, but not FT3 and TSH. The relationship between FT4 within the normal range and CAD may be affected by age.
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来源期刊
CiteScore
0.60
自引率
0.00%
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0
审稿时长
6-12 weeks
期刊介绍: The Journal aims to publish original research and review papers on all fields of geriatrics and gerontology, including those dealing with critical care and emergency medicine. The IJGE aims to explore and clarify the medical science and philosophy in all fields of geriatrics and gerontology, including those in the emergency and critical care medicine. The IJGE is determined not only to be a professional journal in gerontology, but also a leading source of information for the developing field of geriatric emergency and critical care medicine. It is a pioneer in Asia. Topics in the IJGE cover the advancement of diagnosis and management in urgent, serious and chronic intractable diseases in later life, preventive medicine, long-term care of disability, ethical issues in the diseased elderly and biochemistry, cell biology, endocrinology, molecular biology, pharmacology, physiology and protein chemistry involving diseases associated with age. We did not limit the territory to only critical or emergency condition inasmuch as chronic diseases are frequently brought about by inappropriate management of acute problems.
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