{"title":"磷脂双分子层及双分子层与药物相互作用研究中的中子。2小角散射","authors":"M. Belička, Ferdinand Devínsky, P. Balgavý","doi":"10.2478/afpuc-2014-0011","DOIUrl":null,"url":null,"abstract":"Abstract In this paper, we demonstrate several possibilities of using neutron scattering in pharmaceutical research based on examples of scientific results achieved at our University. In this second part, elementary principles of small-angle neutron scattering and simple methods of scattering data evaluation are described. Results of scattering on bilayers in unilamellar liposomes with intercalated general anaesthetics, antimicrobials or cholesterol demonstrate the potential of this method at determination of structural properties of bilayers.","PeriodicalId":7321,"journal":{"name":"Acta Facultatis Pharmaceuticae Universitatis Comenianae","volume":"21 1","pages":"12 - 20"},"PeriodicalIF":0.0000,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. II. Small-angle scattering\",\"authors\":\"M. Belička, Ferdinand Devínsky, P. Balgavý\",\"doi\":\"10.2478/afpuc-2014-0011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract In this paper, we demonstrate several possibilities of using neutron scattering in pharmaceutical research based on examples of scientific results achieved at our University. In this second part, elementary principles of small-angle neutron scattering and simple methods of scattering data evaluation are described. Results of scattering on bilayers in unilamellar liposomes with intercalated general anaesthetics, antimicrobials or cholesterol demonstrate the potential of this method at determination of structural properties of bilayers.\",\"PeriodicalId\":7321,\"journal\":{\"name\":\"Acta Facultatis Pharmaceuticae Universitatis Comenianae\",\"volume\":\"21 1\",\"pages\":\"12 - 20\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-12-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Facultatis Pharmaceuticae Universitatis Comenianae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2478/afpuc-2014-0011\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Facultatis Pharmaceuticae Universitatis Comenianae","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/afpuc-2014-0011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. II. Small-angle scattering
Abstract In this paper, we demonstrate several possibilities of using neutron scattering in pharmaceutical research based on examples of scientific results achieved at our University. In this second part, elementary principles of small-angle neutron scattering and simple methods of scattering data evaluation are described. Results of scattering on bilayers in unilamellar liposomes with intercalated general anaesthetics, antimicrobials or cholesterol demonstrate the potential of this method at determination of structural properties of bilayers.
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