儿科外科患者血清ccl2 / mcp-1水平作为围手术期疼痛管理充分性指标的研究

IF 0.2 Q4 ANESTHESIOLOGY Anaesthesia, Pain & Intensive Care Pub Date : 2021-09-30 DOI:10.25284/2519-2078.3(96).2021.242145
Y. Babina, D. V. Dmitriev, O. Nazarchuk, M. Faustova
{"title":"儿科外科患者血清ccl2 / mcp-1水平作为围手术期疼痛管理充分性指标的研究","authors":"Y. Babina, D. V. Dmitriev, O. Nazarchuk, M. Faustova","doi":"10.25284/2519-2078.3(96).2021.242145","DOIUrl":null,"url":null,"abstract":"BACKGROUND. Surgical treatment leads to the development of postoperative pain in 80% of cases. Therefore, prompt and effective pain management is among the key priorities for healthcare professionals.\nThe aim of the study is to determine the CCL2 / MCP-1 level in the blood serum of patients in the postoperative period under different analgesic methods and to assess the relationship between the inflammatory response and the pain response using the Visual Analog Scale (VAS).\nMaterials and methods. We studied 30 pediatric patients with acute surgical abdominal pathologies, aged 8 to 15 years for urgent surgical procedures requiring general anesthesia. The patients were divided into 3 groups according to selected methods of intraoperative anesthesia: the 1 group included 12 patients, who received standard general anesthesia, the 2 group involved 10 patients, who received general anesthesia and infiltration anesthesia of the wound with 0.5% bupivacaine, a local anesthetic, and the 3 group included 8 children, who received general anesthesia and wound infiltration with 0.5% bupivacaine plus adjuvant (dexamethasone – 4 mg). One hour before surgery and in the postoperative period (3 and 12 hours after surgery), the patients were asked to fill in a pain diary assessing the intensity of pain syndrome and its dynamic characteristics using a visual analogue scale (VAS). Investigation to the rate of inflammatory response was assessed by monocytechemoattractant protein-1 (MCP-1).\nRESULTS. We found out that the plasma CCL2 / MCP-1 level in the patients prior surgery averaged 17.25 ± 7.8 pg / ml; (p <0.05), the baseline plasma CCL2 / MCP-1 levels in the patients of all groups were nearly the same. In patients of the 1st group there was an increase in the level of CCL2 / MCP-1 in the blood plasma (2.3 times) 3 hours after surgery, p <0.05, and 12 hours after surgery, the level of the studied chemokine increased by 6.7 times compared with the results obtained before surgery (p <0,05). Patients in the second group had no increase in inflammatory markers after 3 hours, but after 12 hours after surgery, plasma CCL2 / MCP-1 level significantly increased in 2.2 times compared with the values of the chemokine before surgery (p <0,05). In patients of group 3, the level of CCL2 / MCP-1 in blood plasma did not change statistically at 3 hours and 12 hours after surgery, although on average it decreased quantitatively. In the preoperative period the pain intensity ranked by the VAS scale averaged 7.8 scores and almost did not differ in the all study groups, but in the postoperative period, the degree of pain intensity was quantitatively the lowest in group 3 compared with 1 and 2 study groups.\nCONCLUSION. The dynamics of plasma CCL2 / MCP-1 levels in the patients reflects the development of the general adaptation syndrome in response to trauma. The CCL2 / MCP-1 level is significantly influenced by the type of anesthesia. The multimodal approach to the pain management is considered as the most effective and optimal method in perioperative care of patients","PeriodicalId":7735,"journal":{"name":"Anaesthesia, Pain & Intensive Care","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"INVESTIGATION OF CCL2/MCP-1 LEVEL IN BLOOD SERUM OF SURGICAL PAEDIATRIC PATIENTS AS MARKER OF ADEQUACY OF PERIOPERATIVE PAIN MANAGEMENT\",\"authors\":\"Y. Babina, D. V. Dmitriev, O. Nazarchuk, M. Faustova\",\"doi\":\"10.25284/2519-2078.3(96).2021.242145\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND. Surgical treatment leads to the development of postoperative pain in 80% of cases. Therefore, prompt and effective pain management is among the key priorities for healthcare professionals.\\nThe aim of the study is to determine the CCL2 / MCP-1 level in the blood serum of patients in the postoperative period under different analgesic methods and to assess the relationship between the inflammatory response and the pain response using the Visual Analog Scale (VAS).\\nMaterials and methods. We studied 30 pediatric patients with acute surgical abdominal pathologies, aged 8 to 15 years for urgent surgical procedures requiring general anesthesia. The patients were divided into 3 groups according to selected methods of intraoperative anesthesia: the 1 group included 12 patients, who received standard general anesthesia, the 2 group involved 10 patients, who received general anesthesia and infiltration anesthesia of the wound with 0.5% bupivacaine, a local anesthetic, and the 3 group included 8 children, who received general anesthesia and wound infiltration with 0.5% bupivacaine plus adjuvant (dexamethasone – 4 mg). One hour before surgery and in the postoperative period (3 and 12 hours after surgery), the patients were asked to fill in a pain diary assessing the intensity of pain syndrome and its dynamic characteristics using a visual analogue scale (VAS). Investigation to the rate of inflammatory response was assessed by monocytechemoattractant protein-1 (MCP-1).\\nRESULTS. We found out that the plasma CCL2 / MCP-1 level in the patients prior surgery averaged 17.25 ± 7.8 pg / ml; (p <0.05), the baseline plasma CCL2 / MCP-1 levels in the patients of all groups were nearly the same. In patients of the 1st group there was an increase in the level of CCL2 / MCP-1 in the blood plasma (2.3 times) 3 hours after surgery, p <0.05, and 12 hours after surgery, the level of the studied chemokine increased by 6.7 times compared with the results obtained before surgery (p <0,05). Patients in the second group had no increase in inflammatory markers after 3 hours, but after 12 hours after surgery, plasma CCL2 / MCP-1 level significantly increased in 2.2 times compared with the values of the chemokine before surgery (p <0,05). In patients of group 3, the level of CCL2 / MCP-1 in blood plasma did not change statistically at 3 hours and 12 hours after surgery, although on average it decreased quantitatively. In the preoperative period the pain intensity ranked by the VAS scale averaged 7.8 scores and almost did not differ in the all study groups, but in the postoperative period, the degree of pain intensity was quantitatively the lowest in group 3 compared with 1 and 2 study groups.\\nCONCLUSION. The dynamics of plasma CCL2 / MCP-1 levels in the patients reflects the development of the general adaptation syndrome in response to trauma. The CCL2 / MCP-1 level is significantly influenced by the type of anesthesia. The multimodal approach to the pain management is considered as the most effective and optimal method in perioperative care of patients\",\"PeriodicalId\":7735,\"journal\":{\"name\":\"Anaesthesia, Pain & Intensive Care\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2021-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anaesthesia, Pain & Intensive Care\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.25284/2519-2078.3(96).2021.242145\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ANESTHESIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anaesthesia, Pain & Intensive Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25284/2519-2078.3(96).2021.242145","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景。手术治疗导致80%的病例出现术后疼痛。因此,及时有效的疼痛管理是医疗保健专业人员的关键优先事项之一。本研究的目的是测定不同镇痛方式下术后患者血清CCL2 / MCP-1水平,并采用视觉模拟评分(VAS)评估炎症反应与疼痛反应的关系。材料和方法。我们研究了30例患有急性外科腹部疾病的儿童患者,年龄8至15岁,需要全身麻醉的紧急外科手术。根据术中麻醉方式的选择将患者分为3组:1组12例患者,采用标准全麻;2组10例患者,采用0.5%布比卡因局部麻醉及伤口浸润麻醉;3组8例患儿,采用0.5%布比卡因加辅助剂(地塞米松- 4mg)全麻及伤口浸润麻醉。术前1小时和术后3小时(术后12小时)分别填写疼痛日记,用视觉模拟量表(VAS)评估疼痛综合征的强度及其动态特征。采用单核细胞引诱蛋白-1 (MCP-1)评价炎症反应率。我们发现患者术前血浆CCL2 / MCP-1水平平均为17.25±7.8 pg / ml;各组患者血浆CCL2 / MCP-1基线水平基本相同(p <0.05)。第一组患者术后3小时血浆CCL2 / MCP-1水平升高(2.3倍),p <0.05;术后12小时血浆趋化因子水平较术前升高6.7倍(p <0.05)。第二组患者术后3小时炎症标志物无升高,但术后12小时血浆CCL2 / MCP-1水平较术前升高了2.2倍(p < 0.05)。3组患者术后3小时、12小时血浆CCL2 / MCP-1水平均有定量下降,但无统计学变化。术前疼痛强度VAS评分平均为7.8分,各研究组之间几乎没有差异,但术后3组疼痛强度定量最低,1组和2组疼痛强度最低。患者血浆CCL2 / MCP-1水平的动态变化反映了创伤后一般适应综合征的发展。CCL2 / MCP-1水平受麻醉类型的显著影响。多模式疼痛管理方法被认为是围手术期护理中最有效和最佳的方法
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
INVESTIGATION OF CCL2/MCP-1 LEVEL IN BLOOD SERUM OF SURGICAL PAEDIATRIC PATIENTS AS MARKER OF ADEQUACY OF PERIOPERATIVE PAIN MANAGEMENT
BACKGROUND. Surgical treatment leads to the development of postoperative pain in 80% of cases. Therefore, prompt and effective pain management is among the key priorities for healthcare professionals. The aim of the study is to determine the CCL2 / MCP-1 level in the blood serum of patients in the postoperative period under different analgesic methods and to assess the relationship between the inflammatory response and the pain response using the Visual Analog Scale (VAS). Materials and methods. We studied 30 pediatric patients with acute surgical abdominal pathologies, aged 8 to 15 years for urgent surgical procedures requiring general anesthesia. The patients were divided into 3 groups according to selected methods of intraoperative anesthesia: the 1 group included 12 patients, who received standard general anesthesia, the 2 group involved 10 patients, who received general anesthesia and infiltration anesthesia of the wound with 0.5% bupivacaine, a local anesthetic, and the 3 group included 8 children, who received general anesthesia and wound infiltration with 0.5% bupivacaine plus adjuvant (dexamethasone – 4 mg). One hour before surgery and in the postoperative period (3 and 12 hours after surgery), the patients were asked to fill in a pain diary assessing the intensity of pain syndrome and its dynamic characteristics using a visual analogue scale (VAS). Investigation to the rate of inflammatory response was assessed by monocytechemoattractant protein-1 (MCP-1). RESULTS. We found out that the plasma CCL2 / MCP-1 level in the patients prior surgery averaged 17.25 ± 7.8 pg / ml; (p <0.05), the baseline plasma CCL2 / MCP-1 levels in the patients of all groups were nearly the same. In patients of the 1st group there was an increase in the level of CCL2 / MCP-1 in the blood plasma (2.3 times) 3 hours after surgery, p <0.05, and 12 hours after surgery, the level of the studied chemokine increased by 6.7 times compared with the results obtained before surgery (p <0,05). Patients in the second group had no increase in inflammatory markers after 3 hours, but after 12 hours after surgery, plasma CCL2 / MCP-1 level significantly increased in 2.2 times compared with the values of the chemokine before surgery (p <0,05). In patients of group 3, the level of CCL2 / MCP-1 in blood plasma did not change statistically at 3 hours and 12 hours after surgery, although on average it decreased quantitatively. In the preoperative period the pain intensity ranked by the VAS scale averaged 7.8 scores and almost did not differ in the all study groups, but in the postoperative period, the degree of pain intensity was quantitatively the lowest in group 3 compared with 1 and 2 study groups. CONCLUSION. The dynamics of plasma CCL2 / MCP-1 levels in the patients reflects the development of the general adaptation syndrome in response to trauma. The CCL2 / MCP-1 level is significantly influenced by the type of anesthesia. The multimodal approach to the pain management is considered as the most effective and optimal method in perioperative care of patients
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
0.40
自引率
0.00%
发文量
56
审稿时长
4 weeks
期刊最新文献
NSAIDs in COVID-19, friend or foe? Post cervical spine surgery hyperpyrexia (108?F) in a patient with COVID-19: a case report Extreme physical exhaustion leading to hypokalemic periodic paralysis- a case report Difficult airway management in Apert syndrome for maxillofacial reconstruction: a case report Anesthesia without opioids
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1