铂和铜支持的功能化二氧化钛纳米颗粒用于治疗宫颈癌和前列腺癌

T. López, P. Larraza, E. Gómez
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引用次数: 4

摘要

今天,癌症是导致死亡的主要原因之一。最常见的治疗方法是化疗、手术、放射学和放射外科。催化纳米医学是一个新的研究分支,专注于制备具有医疗应用的纳米生物材料,以创造靶向治疗。本研究的目的是确定铂纳米颗粒(NPt)和铜纳米颗粒(NP-Cu)在癌细胞系以及宫颈癌(HeLa)、前列腺癌(DU 145)的健康细胞中的细胞毒性作用。采用溶胶-凝胶法合成了用于破坏含氮碱中C-C、C- n和C=O键的纳米催化剂。事实证明,它们具有生物相容性和无毒性。用功能化二氧化钛(TiO2)支撑的铂和铜跨越细胞屏障。体外实验结果表明,NPt纳米颗粒比NP-Cu纳米颗粒慢得多。
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Platinum and Copper Supported in Functionalized Titania Nanoparticles for the Treatment of Cervical and Prostate Cancer
Today, cancer is one of the main causes of mortality. The most common treatments are chemotherapy, surgery, radiology and radiosurgery. The catalytic nanomedicine is a new research branch focused on the preparation of nanobiomaterials with medical applications to create a targeted therapy. The goal of this study was to determine the cytotoxic effect of the platinum nanoparticle (NPt) and the copper nanoparticle (NP-Cu) in lines of cancer cells as well as healthy cells for the cervical uterus cancer (HeLa), prostate cancer (DU 145). The catalyst nanoparticles used to break the bonds C-C, C-N and C=O in nitrogenous bases were synthesized in a sol-gel process. It is proven that they were biocompatible and non-toxic. Cell barriers were crossed with platinum and copper supported on functionalized titania (TiO2). In vitro tests were performed giving as a result that the NPt nanoparticles are much slower than the NP-Cu ones.
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