汉药款冬花所含6-乙酰-2,2-二甲基-4-染色质的合成

Nippon Kagaku Kaishi Pub Date : 2002-02-10 DOI:10.1246/NIKKASHI.2002.247

正幸野村, 政夫加藤, 寛次佐藤, 信夫安倍

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摘要

6-乙酰基-2,2-二甲基-4-铬romanone(6)，从Tussilago farfara LINN中分离。用氧化铬(VI)在乙酸酐和乙酸中氧化6-乙基-2,2-二甲基-4-铬酮(4)。以五氧化二磷为原料，以酯3为中间体，对乙基苯酚和3-甲基丁酸在多磷酸中缩合得到化合物4。在没有五氧化二磷的情况下，用玻璃球搅拌反应混合物，3到4的转化也能有效地进行。

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漢薬款冬花に含まれる6-アセチル-2,2-ジメチル-4-クロマノンの合成

6-Acetyl-2,2-dimethyl-4-chromanone(6), isolated from Tussilago farfara LINN., was prepared by oxidation of 6-ethyl-2,2-dimethyl-4-chromanone(4) using chromium(VI) oxide in acetic anhydride and acetic acid. The compound 4 was obtained, via the intermediate of ester 3, by condensation of p-ethylphenol and 3-methylcrotonic acid using diphosphorus pentaoxide in polyphsphoric acid. The conversion of 3 to 4 also proceeds efficiently by stirring of the reaction mixture with glass globes in the absence of diphosphorus pentaoxide.

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Nippon Kagaku Kaishi

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