A. Jaiswal, S. Agrawal, S. Jaiswal, K. Das, S. Behari, S. Tewari, Madam Mohan Godbole, P. Misra
{"title":"脑胶质瘤中BRAF基因状态的评估","authors":"A. Jaiswal, S. Agrawal, S. Jaiswal, K. Das, S. Behari, S. Tewari, Madam Mohan Godbole, P. Misra","doi":"10.31487/j.nnb.2021.03.02","DOIUrl":null,"url":null,"abstract":"Background: Development of different molecular markers has given a new insight in the glioma \nmanagement. KIAA1549-BRAF gene fusion has a diagnostic and prognostic significance. \nAim: The aim of this study was to determine the KIAA1549-BRAF gene fusion in glioma and their \ncorrelation with various clinical parameters.\nMaterial and Methods: Forty cases of glioma were studied for KIAA1549-BRAF gene fusion by reverse \ntranscription-PCR (RT-PCR).\nResults: Overall, KIAA1549-BRAF gene fusion was found in 22% (9/40) cases of glioma. Children had \nhigher KIAA1549-BRAF fusion (72%; 8/11) as compared to adults (10%; 3/29) and this difference was \nstatistically significant. Cerebellar location of tumor was significantly associated with KIAA1549-BRAF\nfusion. KIAA1549-BRAF fusion was highest in pilocytic astrocytoma (89%), and this difference was \nstatistically significant. Statistically significant difference was noted between KIAA1549-BRAF fusion \nexpression and WHO grade I glioma. \nConclusion: Overall, KIAA1549-BRAF gene fusion was found in 22% (9/40) cases of glioma. Childhood \nage, pilocytic astrocytoma histology, cerebellar location and WHO grade I tumor were significantly \nassociated with KIAA1549-BRAF gene fusion.","PeriodicalId":19179,"journal":{"name":"Neurology and Neurobiology","volume":"17 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of BRAF Gene Status in Gliomas\",\"authors\":\"A. Jaiswal, S. Agrawal, S. Jaiswal, K. Das, S. Behari, S. Tewari, Madam Mohan Godbole, P. Misra\",\"doi\":\"10.31487/j.nnb.2021.03.02\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Development of different molecular markers has given a new insight in the glioma \\nmanagement. KIAA1549-BRAF gene fusion has a diagnostic and prognostic significance. \\nAim: The aim of this study was to determine the KIAA1549-BRAF gene fusion in glioma and their \\ncorrelation with various clinical parameters.\\nMaterial and Methods: Forty cases of glioma were studied for KIAA1549-BRAF gene fusion by reverse \\ntranscription-PCR (RT-PCR).\\nResults: Overall, KIAA1549-BRAF gene fusion was found in 22% (9/40) cases of glioma. Children had \\nhigher KIAA1549-BRAF fusion (72%; 8/11) as compared to adults (10%; 3/29) and this difference was \\nstatistically significant. Cerebellar location of tumor was significantly associated with KIAA1549-BRAF\\nfusion. KIAA1549-BRAF fusion was highest in pilocytic astrocytoma (89%), and this difference was \\nstatistically significant. Statistically significant difference was noted between KIAA1549-BRAF fusion \\nexpression and WHO grade I glioma. \\nConclusion: Overall, KIAA1549-BRAF gene fusion was found in 22% (9/40) cases of glioma. Childhood \\nage, pilocytic astrocytoma histology, cerebellar location and WHO grade I tumor were significantly \\nassociated with KIAA1549-BRAF gene fusion.\",\"PeriodicalId\":19179,\"journal\":{\"name\":\"Neurology and Neurobiology\",\"volume\":\"17 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurology and Neurobiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31487/j.nnb.2021.03.02\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurology and Neurobiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31487/j.nnb.2021.03.02","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Background: Development of different molecular markers has given a new insight in the glioma
management. KIAA1549-BRAF gene fusion has a diagnostic and prognostic significance.
Aim: The aim of this study was to determine the KIAA1549-BRAF gene fusion in glioma and their
correlation with various clinical parameters.
Material and Methods: Forty cases of glioma were studied for KIAA1549-BRAF gene fusion by reverse
transcription-PCR (RT-PCR).
Results: Overall, KIAA1549-BRAF gene fusion was found in 22% (9/40) cases of glioma. Children had
higher KIAA1549-BRAF fusion (72%; 8/11) as compared to adults (10%; 3/29) and this difference was
statistically significant. Cerebellar location of tumor was significantly associated with KIAA1549-BRAF
fusion. KIAA1549-BRAF fusion was highest in pilocytic astrocytoma (89%), and this difference was
statistically significant. Statistically significant difference was noted between KIAA1549-BRAF fusion
expression and WHO grade I glioma.
Conclusion: Overall, KIAA1549-BRAF gene fusion was found in 22% (9/40) cases of glioma. Childhood
age, pilocytic astrocytoma histology, cerebellar location and WHO grade I tumor were significantly
associated with KIAA1549-BRAF gene fusion.
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