细菌性甲沟炎继发念珠菌甲沟炎1例

M. Nishida, T. Iizuka, T. Hamaguchi, J. Ninomiya, I. Takiuchi
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摘要

我们报告一例78岁的家庭主妇与念珠菌甲甲·甲趾。这个病人患支气管哮喘已有多年了。偶尔也会静脉注射皮质类固醇。1995年6月10日因左大脚趾甲襞出现红斑伴轻度肿胀钝痛来我科就诊。在就诊前一个月,她接受了咯血抗生素治疗,几周后,左大脚趾尖开始弥漫性肿胀。她注意到疼痛加剧,尽管在她就诊前三四天伤口流出脓后剧痛自然减轻了。脚趾有轻微的红斑和肿胀,并有干燥的脓疱。甲角质层和甲手套有明显的剥落鳞片。通过KOH法直接检查,在病变的鳞片和甲板中检测到大量菌丝和葡萄状孢子的真菌成分。从病变中分离出的生物被鉴定为白色念珠菌血清型A,尽管没有培养细菌。局部应用抗真菌试剂治疗7周后,病灶完全消失。据我们所知,在日本仅报告了4例甲状念珠菌。我们怀疑我们的病例合并了细菌性甲沟炎。
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A Case of Candida Paronychia·Onychia of a Toe Following Bacterial Paronychia
We report the case of a 78-year-old housewife with candida paronychia·onychia of a toe. The patient has suffered for a number of years from bronchial asthma. and has occasionally been intravenously injected with corticosteroid. On June 10, 1995, she visited our department because she developed erythema with slight swelling and dull pain on the nail fold of her left big toe. During the month prior to her visit, she was treated with antibiotics for hemoptysis, and few weeks later, the tip of the left big toe became diffusely swollen. She noticed an increase in pain, although sharp pain lessened spontaneously after the wound discharged pus three or four days before she visited us. The toe exhibited slight erythema and swelling with dried pustules. Marked exfoliative scales were present in the nail cuticle and the nail glove. Numerous fungal elements of hyphae and grape-shaped spores were detected in the scales and nail plates of the lesion by a direct examination using the KOH method. Organisms isolated from the lesions were identified as Candida albicans serotype A, although no bacteria was cultured. The leisons completely disappeared after 7 weeks therapy with topical application of an antifungal reagent.To our knowledge, only 4 cases of candida paronychia·onychia of the toe have been reported in Japan. We suspect our case to have been complicated with bacterial paronychia.
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