正确的病人,正确的诊断,正确的治疗!

D. Saranath, A. Khanna
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引用次数: 0

摘要

2015年诺贝尔医学奖因治疗疟疾和其他热带疾病的药物获得,诺贝尔化学奖因在理解DNA修复和维持细胞基因组完整性方面做出的重要贡献获得,这凸显了跨学科方法可以最大限度地使当代科学造福人类。诺贝尔医学奖授予威廉·坎贝尔博士,出生于爱尔兰,移民美国;来自日本的大村智博士和中国第一位诺贝尔奖得主屠呦呦。诺贝尔奖得主坎贝尔博士和大村博士因发现阿维菌素而获奖。阿维菌素是阿维菌素的衍生物,它降低了影响亚洲和非洲数百万人的河盲症和淋巴丝虫病的发病率。屠女士的不懈努力使我们从中药青蒿植物中提取了活性化合物,使我们有了抗疟疾药物青蒿素,这是目前治疗影响全球50%人口的疟疾的一线药物。诺贝尔化学奖表彰了三位科学家在DNA修复方面的研究,他们在分子水平上绘制修复过程的密集工作,为细胞功能和基因组稳定性的维持提供了见解。诺贝尔奖得主是伦敦弗朗西斯克里克研究所的托马斯林达尔博士,因其在碱基切除修复方面的发现;Howard Hughes医学研究所的Paul Modrich博士和美国北卡罗莱纳州杜克大学医学院的错配修复途径;和美国北卡罗来纳大学的Aziz Sancar博士,m.d., Ph.D.,研究核苷酸切除途径。对细胞中DNA修复机制的理解是理解癌症如何发展和进一步治疗癌症和其他疾病的一个突破,这对更好的健康管理非常必要。尽管技术取得了巨大进步,特别是生物技术、信息技术和成像技术,但癌症的发展,Dhananjaya Saranath和Aparna Khanna
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Right patient, right diagnosis, right treatment!
The 2015 Nobel Prize in Medicine for drugs to fight malaria and other tropical diseases, and in Chemistry for fundamental contributions towards understanding DNA repair and maintaining of genomic integrity in cells, highlights the interdisciplinary approach for maximizing benefits of contemporary science to mankind. The Nobel Prize in Medicine was awarded to William Campbell Ph.D., born in Ireland and migrated to US; Satoshi Omura, Ph.D., from Japan, and Youyou Tu, the first Chinese Nobel laureate. The Nobel laureates – Dr. Campbell and Dr. Omura were cited for their discovery of Avermecitin, derivatives of the drug responsible for decreasing incidence of river blindness and lymphatic filariasis affecting millions in Asia and Africa. Ms. Tu's intensive efforts led to the active compound from the herbal Chinese sweet wormwood plant, giving us the antimalarial drug artemisinin, currently the first line drug for malaria affecting 50% of global population. The Chemistry Nobel acknowledged three scientists for their research in DNA repair, for their intensive work on mapping the process at a molecular level and providing insights into cell functioning and maintenance of genomic stability. The Nobel laureates were Dr. Thomas Lindahl, Ph.D., Francis Crick Institute, London, for his discoveries in base excision repair; Dr. Paul Modrich, Ph.D., Howard Hughes Medical Institute, and Duke University School of Medicine, North Carolina, USA, for the mismatch repair pathway; and Dr. Aziz Sancar, M.D., Ph.D., at the University of North Carolina, USA, for nucleotide excision pathway. The understanding of DNA repair mechanisms in the cells is a breakthrough in understanding how cancer develops and furthers treatment of cancer and also several diseases, much needed for better health management. Despite the tremendous advances in technology, particularly biotechnology, information technology and imaging technology, cancer development, Dhananjaya Saranath and Aparna Khanna
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