Neuromuscular Adaptations after Blood Flow Restriction Training Combined with Nutritional Supplementation: A Preliminary Study

Blood fl ow restriction training (BFRT) has been shown to be an eff ective alternative technique to conventional resistance training to increase skeletal muscle hypertrophy and strength. However, neuromuscular response to BFRT in combination with nutritional supplementation has rarely been studied. Th e purpose of this study was to investigate the eff ects of BFRT combined with creatine monohydrate (CrM) and/or hydroxymethyl butyrate (HMB) on skeletal muscle size and strength. Fift een healthy males were randomly divided into three groups: a) BFRT without supplementation (C-BFR); b) BFRT with CrM supplementation (0.3 g / kg-1) (CrM-BFR); and c) BFRT with CrM (0.3 g / kg-1) and HMB (3 g) supplementation (CrM + HMB-BFR). Participants performed elbow fl exion exercise (30% of maximal isometric voluntary contraction (MIVC)) at 30% of total occlusion pressure, twice a week, for three weeks. MIVC of the elbow fl exion and brachial biceps muscle thickness were assessed preand post-training. Th ere was no signifi cant group-by-time interaction for MIVC values (p>0.05). Biceps muscle thickness was signifi cantly increased from preto post-test in all groups (p<0.05). Th e C-BFR group obtained a greater value of eff ect size (d=2.2). Th ese fi ndings suggest that 3 weeks of CrM and HMB supplementation had no infl uence on BFRT-induced neuromuscular adaptations.