探讨银屑病与妊娠的关系:系统文献综述

Pratiksha Patra
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引用次数: 1

摘要

本系统的文献综述探讨牛皮癣和妊娠之间的关系,以阐明可能的新治疗途径。本综述的发现有助于缩小关于该主题的文献差距,并教育医生和患有牛皮癣的孕妇了解牛皮癣如何在怀孕期间及其后出现。搜索主要在三个数据库中进行:PubMed、Scopus和Embase。考虑纳入本文献综述的文章主要集中在妊娠期间牛皮癣的表现。获得的文献样本包括2012-2022年间发表的14篇同行评议文章。随着代码被识别,一个主代码列表被开发出来。第二个周期编码涉及对数据进行分类,允许代码组合并作为主题出现。通过分类分析确定了五个主题:免疫学、一般性激素、雌激素、黄体酮和HLA-Cw6等位基因。总的来说,这些发现阐明了牛皮癣的个体性质,并确定黄体酮是一种可能的非致畸治疗。首先,女性基因组中HLA-Cw6等位基因的存在以及雌激素受体的个体差异加强了研究人员在牛皮癣诊断后进行基因检测的建议。这种基因检测可以让患者和医生更好地了解怀孕期间牛皮癣的情况,并帮助确定最有效的治疗方案。
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Exploring the Relationship between Psoriasis and Pregnancy: A Systematic Literature Review
This systematic literature review examines the relationship between psoriasis and pregnancy to elucidate possible new routes of treatment. Findings from this review help reduce the gap in the literature on the topic as well as educate physicians and pregnant women with psoriasis on how psoriasis may present along the course of pregnancy and thereafter. Searches were primarily conducted in three databases: PubMed, Scopus, and Embase. Articles considered for inclusion in this literature review focused on the presentation of psoriasis during pregnancy. The literature sample obtained consisted of 14 peer-reviewed articles published from 2012-2022. As codes were identified, a master code list was developed. Second cycle coding involved categorizing of the data allowing for codes to combine and emerge as themes. Five themes were identified through categorical analysis: immunology, general sex hormones, estrogen, progesterone, and the HLA-Cw6 allele. Collectively, these findings elucidate the individual nature of psoriasis and identify progesterone as a possible non-teratogenic therapy. Primarily, the presence of the HLA-Cw6 allele in a woman’s genome along with the individual variation of estrogen receptors reinforces the researcher’s recommendation of genetic testing following a psoriasis diagnosis. This genetic testing may allow patients and physicians to best understand what to expect of psoriasis during pregnancy as well as help determine the most efficacious treatment course to follow for therapy.
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