一项初步的随机、单盲、安慰剂对照的临床剂量反应研究,旨在阐明给药东方布兰后持续等距肌肉收缩对肺肺活量的影响

Usha Kushwaha, G. Supriya, Balakrishnan Nair, K. Chattopadhyay, Ashwini Nair, Sanjay Vishwakarma
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引用次数: 0

摘要

简介:东方布兰是顺势疗法药物中治疗哮喘和其他慢性阻塞性肺疾病的适应症药物。临床前研究表明,当乙酰胆碱诱导支气管痉挛时,东方蓟通过非选择性抗胆碱能和抗组胺活性表现出抗哮喘特性。然而,没有研究探索在使用顺势疗法药物B. orientalis时肺部肺活量的变化。结果表明,胸肌的等长收缩通过增加通气和降低肺泡二氧化碳分压来增强肺活量。它可以作为一个有价值的工具,监测肺的肺活量前后给药。目的:本初步研究通过一项随机、安慰剂对照研究,向探索肺活量迈出了第一步,阐明了不同剂量的东方蓟对健康个体持续等距肌肉收缩对肺活量的影响。它的目的是比较在健康参与者的肺活量的变化,在急性发作等距收缩后,由手握测力仪给药。材料与方法:18名符合纳入标准的受试者自愿同意参加本研究。研究小组在基线时测量了这些参与者的Tmax(用握力计测量)和肺活量(用生命记录仪测量)。然后,参与者被分为三种药物组,口服药物:第1组-东方B. Q,第2组-东方B. 30C,第3组-安慰剂,每个药物组分配6名参与者。采用抽签法将参与者随机分组到每个药物组。参与者使用摇号法从1到18编号,并确保每个手臂有一名男性和五名女性具有相似的性别分布。研究小组用布绷带蒙住参与者的眼睛,然后将他们分为不同的药物组。研究小组测量了每个参与者的Tmax和肺活量,然后给他们服用一剂指定的药物。研究小组在给药10分钟后测量了参与者的Tmax和肺活量。每隔24 h重复该过程,连续3天。结果:骨骼肌持续等长收缩对肺活量的影响是衡量肺活量改善的重要工具。口服B. orientalis Q和B. orientalis 30C后,肺的肺活量显著降低,而在接受安慰剂的手臂中没有发现明显的影响。结论:本初步研究表明,东方蓟具有降低健康人肺活量的作用,需要在更高的效价和更广泛的实验参数上进一步探索其作用。根据相似定律,这一推断也增加了顺势疗法药物在限制性肺疾病患者中潜力的研究范围,这些患者的重要肺活量明显下降。
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A preliminary randomized, single-blinded, placebo-controlled clinical dose–response study to elucidate the effect of ongoing isometric contraction of muscles on the vital capacity of lungs on administering Blatta orientalis
INTRODUCTION: Blatta orientalis is an indicated remedy for asthma and other chronic obstructive pulmonary diseases in homeopathic medicine. Preclinical studies indicate that B. orientalis shows anti-asthmatic properties in animals when induced with bronchospasm using acetylcholine through nonselective anticholinergic and antihistaminic activities. However, no studies have explored the changes in the vital capacity of the lungs on administering the homeopathic remedy, B. orientalis. It is shown that isometric contraction of pectoral muscles enhances the vital capacity of lungs by increasing ventilation and decreasing alveolar partial pressure of carbon dioxide. It can act as a valuable tool for monitoring the vital capacity of the lungs before and after administration of B. orientalis. AIM: This preliminary research takes the first step toward exploring vital capacity through a randomized, placebo-controlled study elucidating the effects of ongoing isometric contraction of muscles on the vital capacity of lungs of healthy individuals on the administration of B. orientalis in different potencies. It aims to compare changes in the vital capacity of lungs in healthy participants during an acute bout of isometric contraction by handgrip dynamometer after administration of B. orientalis. MATERIALS AND METHODS: Eighteen participants who fulfilled the inclusion criteria gave voluntary consent to participate in this research study. The research team measured the Tmax (measured by handgrip dynamometer) and the vital capacity (measured by a vitalograph) of these participants at the baseline. The participants were then placed into three-medicine arms to administer medicine orally: Arm 1 – B. orientalis Q, Arm 2 – B. orientalis 30C, and Arm 3 – placebo, following allocation of six participants in each medicine arm. Lottery method was used for grouping participants randomly to each medicine arm. The participants were numbered from 1 to 18 using the lottery method, and it was made sure that each arm had one male and five females to have similar gender distribution. The research team blindfolded the participants with a cloth bandage (dupatta) before categorizing them into different medicine arms. The team measured each participant's Tmax and vital capacity, and then administered one dose of the assigned medicine. The team measured the Tmax and vital capacity of the participants after 10 min of administering the medicine. The process was repeated after every 24 h for 3 consecutive days. RESULTS: The effect of ongoing isometric contractions of the skeletal muscles on the vital capacity acted as a great tool to measure improvement in vital capacity. The vital capacity of the lungs was significantly decreased after oral administration of B. orientalis Q and B. orientalis 30C, whereas there was no significant effect found in the arm that received a placebo. CONCLUSION: This preliminary study shows that B. orientalis decreases the vital capacity of lungs in healthy subjects and calls for further exploration of its action in higher potencies and with wider experimental parameters. Following the Law of Similimum, this inference also adds to the research scope on the potential of this homeopathic medicine in patients with restrictive lung diseases where the vital lung capacity gets significantly decreased.
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