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Clinicopathological correlation of endometrial hyperplasias with progesterone receptor expression in DUB DUB子宫内膜增生与孕激素受体表达的临床病理关系
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_222_22
Zebasultana Saiyed, G. Neethu, MPradeep Kumar Reddy, C. Preethi, S. Bijjaragi
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引用次数: 0
“Matrix Rhythm Therapy (MaRhyThe) and cupping:” A novel multimodal approach for breast cancer-related lymphedema 基质节律疗法(MaRhyThe)和拔罐:一种治疗乳腺癌相关淋巴水肿的新型多模式方法
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_107_22
Renu B Pattanshetty, Nikita Pawar, Mounica Y. Rao
Breast cancer is the second leading cause of cancer mortality in India, with an incidence of 210,801 cases in 2020 and every 29th woman being diagnosed with breast cancer. Among the various treatment options, side effects such as lymphedema are mostly caused due to chemoradiotherapy. Physical therapy is known to be beneficial in treating postcancer treatment side effects. To the best of our knowledge, this is the first study report highlighting the efficacy of Matrix Rhythm Therapy (MaRhyThe©) in treating breast cancer-related lymphedema. A multimodal approach (MaRhyThe©, cupping therapy, and complex decongestive therapy) has shown to be beneficial in treating lymphedema, shoulder disability, pain, and muscle weakness and improving the quality of life in a breast cancer survivor.
乳腺癌是印度癌症死亡的第二大原因,2020年的发病率为210,801例,每29名妇女中就有1名被诊断患有乳腺癌。在各种治疗方案中,淋巴水肿等副作用主要是由放化疗引起的。物理治疗对于治疗癌症后的副作用是有益的。据我们所知,这是第一份强调基质节律疗法(MaRhyThe©)治疗乳腺癌相关淋巴水肿疗效的研究报告。一种多模式治疗方法(MaRhyThe©、火罐疗法和复杂的消血疗法)已被证明对治疗淋巴水肿、肩部残疾、疼痛和肌肉无力以及改善乳腺癌幸存者的生活质量有益。
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引用次数: 0
Determinants of malnutrition among under five children: A cross sectional study in urban Belgaum, India 五岁以下儿童营养不良的决定因素:印度贝尔高姆城市的横断面研究
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_149_22
Vaishali S. Bagewadi, LA Sumita, Sangeeta N Kharde
INTRODUCTION: Malnutrition has become the most common nutritional disorder, and it is one of the main reasons for under-five mortality and morbidity worldwide. In India itself, more than one-third of the global malnourished children are existing. More than half of the children below 3 years are considered underweight among these. It is considered one of the most burning issues, and the common effect of malnutrition is in the form of late physical growth and intellectual development. The aim of this study was to assess the determinants of malnutrition among under-five children. STUDY DESIGN: This was a cross-sectional study with a key informant interview to identify the determinant factors of malnutrition. Four hundred and sixty children with their mothers were participated in the study. Odds ratio with a 95% confidence interval was used to identify the determinants of malnutrition among under-five children using multivariate logistic regression. RESULTS: Among 460 children, more than half of the children, 249 (54.13%), was malnourished. Of these 249 children, 142 were female, while 107 were male. Mother's age, religion, family size, and family income were significantly associated with malnutrition (P < 0.05). CONCLUSION: Malnutrition was higher in female children than male children, and a proper girl child care and educating the mothers regarding the importance of nutrition for their children help overcome the malnutrition problem in our locality.
导读:营养不良已成为最常见的营养失调,是全世界五岁以下儿童死亡和发病的主要原因之一。在印度,全球超过三分之一的营养不良儿童存在。其中超过一半的3岁以下儿童被认为体重过轻。它被认为是最紧迫的问题之一,营养不良的常见影响是身体发育和智力发育迟缓。这项研究的目的是评估五岁以下儿童营养不良的决定因素。研究设计:这是一项横断面研究,通过对关键信息提供者的访谈来确定营养不良的决定因素。460名儿童和他们的母亲参与了这项研究。采用多因素logistic回归,以95%置信区间的优势比确定五岁以下儿童营养不良的决定因素。结果:460名儿童中有249名(54.13%)营养不良。在这249名儿童中,142名是女性,107名是男性。母亲年龄、宗教信仰、家庭规模、家庭收入与营养不良有显著相关(P < 0.05)。结论:女童营养不良发生率高于男童,对女童进行适当的护理,并对母亲进行营养教育,有助于解决本地区儿童营养不良问题。
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引用次数: 0
Extradigital glomus tumor – A rare case report 指外血管球瘤1例
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_122_22
Ashwini Ratnakar, Manasi Gosavi, P. Bhat
Glomus tumor is benign vascular tumors arising from modified smooth muscle cells of the glomus bodies and accounting for 1.6% of all soft-tissue tumors. The presence of glomus tumors at sites other than fingertips is a very rare occurrence. We present a rare case of a 68-year-old male with a history of painful nodules over the interscapular region for the last 10 years which was excised and sent to our department of pathology. On gross examination, the lesion was 1 × 1 cm, nodular. Cut section was gray and brown with areas of hemorrhage seen. Histopathological examination revealed a circumscribed lesion in the dermis comprising small dilated vascular spaces surrounded by sheets and clusters of glomus cells having round–oval, bland nucleus with moderate-abundant eosinophilic cytoplasm. No areas with increased mitosis, no atypia, and no necrotic areas were seen. There was no area with ductal/mucin differentiation. Glomus tumor is very rare at extradigital sites and may be often missed clinically. However, the presence of the characteristic microscopic picture of perivascular sheets of bland, uniform glomus cells should help us arrive at the correct diagnosis and provide appropriate management to the patient.
球囊瘤是由球囊小体的平滑肌细胞修饰而成的良性血管肿瘤,占软组织肿瘤的1.6%。在指尖以外的部位出现血管球瘤是非常罕见的。我们报告一个罕见的病例,68岁男性,肩胛间区疼痛结节的历史,过去10年被切除并送到我们的病理科。大体检查,病变大小为1 × 1 cm,结节状。切面呈灰褐色,可见出血区。组织病理学检查显示真皮内有一个界限分明的病变,包括小的扩张的血管间隙,周围有片状和簇状的血管球细胞,细胞核呈圆形,细胞核温和,嗜酸性细胞质中等丰富。无有丝分裂增加,无异型性,无坏死区。无导管/粘蛋白分化区。血管球瘤在指外部位是非常罕见的,并且在临床上可能经常被遗漏。然而,血管周围扁平、均匀的血管球细胞的特征性显微镜图像的存在应该有助于我们得出正确的诊断并为患者提供适当的治疗。
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引用次数: 0
Modified work–rest schedule of the handloom weavers: An ergonomic study 手摇织布机织布工调整作息时间的人机工程学研究
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_183_22
Santu Durlov, S. Gangopadhyay, S. Sahu
BACKGROUND: A sustainable work schedule is created by employing proper work and recuperation cycles, as well as balancing high- and low-effort tasks. The work of the handloom weaver was physically and mentally taxing. However, they do not take breaks and work nonstop. Short breaks are good for both physical work and job-related mental and cognitive stress. Therefore, a quick break is used as an intervention. METHODS: Participants in this study included 100 handloom weavers. A modified work–rest plan consists of 50 min of labor and 10 min of rest per hour. To order to calculate Brouha's index, recovery heart rate data were collected after work for 3 min while the participant was seated. Using the flicker-fusion frequency test, visual tiredness was assessed. RESULTS: A newly developed work–rest cycle lessens tiredness and becomes more effective over time. The newly created work–rest plan for the handloom weavers dramatically reduces perceived exertion and energy expenditure. CONCLUSION: The modified work–rest schedule decreased cardiovascular and mental stress. This work–rest schedule will therefore reduce fatigue and help with the work if it is used in this sector.
背景:可持续的工作时间表是通过采用适当的工作和恢复周期,以及平衡高强度和低强度的任务来创建的。手工织布机织工的工作对体力和脑力都很费力。然而,他们不休息,不间断地工作。短暂的休息对体力劳动和与工作相关的精神和认知压力都有好处。因此,快速休息被用作干预。方法:研究对象为100名手工织布机织工。修改后的作息计划为每小时劳动50分钟,休息10分钟。为了计算Brouha指数,在受试者坐下工作3分钟后收集恢复心率数据。使用闪烁融合频率测试评估视觉疲劳。结果:新开发的工作-休息循环减少疲劳,并随着时间的推移变得更有效。新创建的工作-休息计划为手工织布机织布者大大减少劳累和能量消耗。结论:调整作息时间可降低心血管和精神压力。因此,如果在这个部门使用这种工作-休息时间表,将减少疲劳并有助于工作。
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引用次数: 0
Correlation between physical activity level and anterior knee pain in Indian recreational and professional athletes 体育活动水平与印度休闲运动员和职业运动员前膝关节疼痛的相关性
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_125_21
Anjali Tiwari, Prachi Sathe, A. Sathe, D. Kumar
BACKGROUND: Anterior knee pain is one of the most common musculoskeletal complaints seen in the Indian population with high prevalence among those who are active in professional sports and recreational sports. It commonly occurs in many healthy young athletes, especially girls. The aim of the study is to compare the anterior knee pain in recreational and professional athletes. METHODS: This study is done to find the correlation between physical activity and anterior knee pain in recreational and professional athletes, using the Kujala Anterior Knee Pain Scale, Numeric pain rating scale (NPRS), Victorian Institute of Sports Assessment Scale (VISA) for measurement of pain, and International Physical Activity Questionnaire (IPAQ) for measurement of physical activity. A total of 112 recreational and professional athletes participated in the study. Both online and offline mode was used in data collection. RESULTS: There was a correlation between physical activity and anterior knee pain. CONCLUSION: We found a significant negative correlation between IPAQ and Kujala Scores in recreational and professional athletes. A positive correlation between IPAQ and VISA in recreational players and IPAQ and NPRS in professional athletes was found.
背景:前膝关节疼痛是印度人群中最常见的肌肉骨骼疾病之一,在从事专业运动和休闲运动的人群中患病率很高。它常见于许多健康的年轻运动员,尤其是女孩。本研究的目的是比较休闲运动员和职业运动员的膝关节前侧疼痛。方法:采用Kujala膝关节前侧疼痛量表、数字疼痛评定量表(NPRS)、维多利亚体育协会评估量表(VISA)测量疼痛,以及国际体育活动问卷(IPAQ)测量体育活动,探讨体育活动与休闲运动员和职业运动员膝关节前侧疼痛的相关性。共有112名娱乐和专业运动员参加了这项研究。数据采集采用线上和线下两种方式。结果:体力活动与膝关节前侧疼痛之间存在相关性。结论:休闲运动员和职业运动员的IPAQ与Kujala得分呈显著负相关。休闲运动员的IPAQ与VISA、职业运动员的IPAQ与NPRS呈显著正相关。
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引用次数: 0
Venolymphatic malformation – parotid gland 静脉淋巴畸形-腮腺
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_22_23
M. Aishwarya, Manasi Gosavi, Ashwini Ratnakar, M. Togale
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引用次数: 0
Immunogenicity studies of nucleic acid-based antirabies vaccines in BALB/c mice: A systematic review 基于核酸的抗狂犬病疫苗在BALB/c小鼠中的免疫原性研究:系统综述
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_140_22
Hasanthi Rathnadiwakara, F. Cliquet, Chandrindu Abeykoon, R. Jayawardena, M. Wasniewski, M. Gunatilake, J. Thibault
Improved vaccine efficacy has a major impact on future rabies prevention and control. In this systematic review, a comparative assessment of different nucleic acid-based antirabies vaccination tools developed using different methods, in different countries, was undertaken. The comprehensive search was done in three databases. Articles were carefully selected based on predetermined inclusion/exclusion criteria and eight articles were included in this systematic review. Studies have demonstrated dose-dependent immune response following intramuscular vaccination and improved immune response following intranasal vaccination and gene-gun delivery method. Nucleic acid-based antirabies vaccines have shown higher immune response and protective levels in Bagg's albino (BALB/c) mouse models than cell culture-derived vaccines. It has been demonstrated that the route/method of administration and the vaccine formulation could be improved in various ways to enhance immune response following vaccination. These new vaccine tools and their implementation in pre- and postexposure prophylaxis could be further evaluated and to be adopted by rabies endemic countries.
提高疫苗效力对今后狂犬病的预防和控制具有重大影响。在本系统综述中,对不同国家使用不同方法开发的基于核酸的抗狂犬病疫苗接种工具进行了比较评估。在三个数据库中进行了全面的检索。根据预先确定的纳入/排除标准仔细选择文章,本系统评价纳入了8篇文章。研究已经证明肌肉注射疫苗后的剂量依赖性免疫反应和鼻内接种疫苗和基因枪递送方法后的免疫反应得到改善。基于核酸的抗狂犬病疫苗在Bagg's albino (BALB/c)小鼠模型中显示出比细胞培养衍生疫苗更高的免疫应答和保护水平。已经证明,可以通过各种方式改进给药途径/方法和疫苗配方,以增强接种后的免疫反应。这些新的疫苗工具及其在暴露前和暴露后预防中的实施情况可以进一步评估,并由狂犬病流行国家采用。
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引用次数: 0
Role of Vitamin B12 and folate in metabolic syndrome – Current trends and future perspectives 维生素B12和叶酸在代谢综合征中的作用——当前趋势和未来展望
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_71_22
Kowshik Chandramahanti, Akhila Chiratanagandla, Swarnadeep Ammula, Bhargav Kommineni
The metabolic syndrome (MS) refers to a collection of illnesses which together alleviate the potential risk of insulin resistance, atherosclerotic cardiovascular disease, diabetes mellitus, and vascular and neurological outcomes such as the cerebrovascular accident. Vitamin B12 is one of the major water-soluble vitamins found among the animal products such as the dairy products, eggs, and red meat. Folate is an essential nutrient which is naturally present among the foods in a stable reduced form and is present in an oxidized form (folic acid) among the fortified foods and dietary supplements. Homocysteine and methylmalonic acid levels in the blood are raised when Vitamin B12 is deficient, both of them can serve as indicators of deficiency of Vitamin B12 biochemical. Excess folate, primarily from the increased intake of folic acid, can interfere with the metabolism of cobalamin and exacerbates the Vitamin B12 deficiency symptoms, according to previous studies. Furthermore, the influence of supplementing Vitamin B12 and folate remains a largely uncharted field, hence, a lot more observational studies and randomized controlled trials are required to determine how vitamin supplementation affects each and every component of MS.
代谢综合征(MS)是指一系列疾病的集合,这些疾病共同减轻了胰岛素抵抗、动脉粥样硬化性心血管疾病、糖尿病以及血管和神经系统后果(如脑血管意外)的潜在风险。维生素B12是一种主要的水溶性维生素,存在于乳制品、鸡蛋和红肉等动物产品中。叶酸是一种必需的营养物质,在食物中以稳定的还原形式自然存在,在强化食品和膳食补充剂中以氧化形式(叶酸)存在。维生素B12缺乏时,血液中同型半胱氨酸和甲基丙二酸水平升高,两者均可作为维生素B12缺乏的生化指标。根据先前的研究,过量的叶酸(主要来自叶酸摄入量的增加)会干扰钴胺素的代谢,并加剧维生素B12缺乏的症状。此外,补充维生素B12和叶酸的影响仍然是一个很大程度上未知的领域,因此,需要更多的观察性研究和随机对照试验来确定维生素补充如何影响多发性硬化症的每一个组成部分。
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引用次数: 0
Usability of medication event reminder monitoring system and other determinants to improve the adherence to anti-tuberculosis drugs among patients of tertiary care hospital, Hyderabad 用药事件提醒监测系统的可用性和其他决定因素对提高海德拉巴三级医院患者抗结核药物依从性的影响
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_110_22
S. Bala, B. Aravind, Shashanka Kadas, H. Pandve, Sneha Shukla, A. Rajesham, Haritha Arnipalli
INTRODUCTION: Novel strategies to improve the adherence to anti-tuberculosis (TB) drugs include the digital adherence technology for monitoring these patients. The purpose of the study is to determine the acceptability and satisfaction of the medication event reminder monitoring system (MERMS) by the patients and to assess various determinants among adherent and nonadherent groups. MATERIALS AND METHODS: A facility-based cross-sectional study was undertaken among the drug-sensitive TB patients of a TB unit where the MERMS box was issued to them on a pilot basis under the national program. These were assessed on a validated scale of 11 questions graded on a 5-point Likert scale for the usability of MERMS box and various determinants among adherent and Nnonadherent groups were assessed. RESULTS: A total of 126 patients were included in our study with high satisfaction scores for the usage of the MERMS box. There was 89.7% adherence and 10.3% Nonadherence with this and the determinants found to be statistically significant were the large distance of the center from home, loss of daily wages, any of the family problems, Having insufficient money for performing regular investigations, fear of side effects of drugs, social stigma attached, travel cost, long waiting periods at DOTS center, and any toxicity of drugs being experienced. CONCLUSIONS: The usability of MERMS can be enhanced by bringing changes in the font of printed labels and operation instructions and the removal of social stigma can improve adherence.
导读:提高抗结核药物依从性的新策略包括监测这些患者的数字依从性技术。本研究的目的是确定患者对用药事件提醒监测系统(MERMS)的可接受性和满意度,并评估依从组和非依从组的各种决定因素。材料和方法:在结核病单位的药物敏感结核病患者中进行了一项基于设施的横断面研究,在国家计划的试点基础上向他们发放了MERMS箱。这些都是在一个有效的量表上进行评估的11个问题,按照5点李克特量表对MERMS盒的可用性进行评分,并评估粘附组和非粘附组的各种决定因素。结果:我们的研究共纳入126例患者,对MERMS盒的使用满意度得分较高。89.7%的患者坚持服药,10.3%的患者不坚持服药,统计上具有显著意义的决定因素是:中心离家太远,失去日常工资,任何家庭问题,没有足够的钱进行定期检查,害怕药物的副作用,社会污名,旅行费用,在DOTS中心等待时间过长,以及药物的毒性。结论:改变印刷标签和操作说明书的字体可提高MERMS的可用性,消除社会污名可提高依从性。
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引用次数: 0
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BLDE University Journal of Health Sciences
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