幽门螺杆菌感染与溃疡性结肠炎之间的关系:一项荟萃分析研究

Alesia Prillya Mauna, M. Simadibrata
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引用次数: 0

摘要

背景:溃疡性结肠炎(UC)是一种慢性炎症性疾病,可导致出血性腹泻,仍然是全球主要的疾病负担。虽然幽门螺杆菌感染被认为能够减少UC的发生,但它在疾病本身的作用仍然存在争议。因此,本荟萃分析旨在研究幽门螺旋杆菌感染是否可以降低UC的发生机会。方法:通过Cochrane、PubMed、Embase三个电子数据库进行系统检索,并辅以个体手检索,分析成人溃疡性结肠炎与幽门螺杆菌感染的相关性。通过资格标准选择的相关文章通过使用纽卡斯尔-渥太华量表进行质量评估。此外,进行了随机效应荟萃分析,以估计合并奇数比(ORs)及其95%置信区间(ci)。并进行Higgins检验和漏斗图分析。结果:meta分析共纳入了来自22项研究的11498例UC患者和356130例对照。纳入的研究显示质量一般或良好。质量好,选择3星,可比性1星,结果/曝光2星;质量一般,领域2星,可比性1星,结果/曝光2星。我们的研究结果表明,幽门螺杆菌感染与较低的UC发生率相关[合并or为0.51 (95% CI: 0.46-0.56)],尽管存在中等异质性(I2= 54%, p = 0.002)。此外,未发现发表偏倚。结论:本研究增加了越来越多的证据支持幽门螺旋杆菌感染对UC发生的潜在保护作用。然而,需要进一步进行前瞻性研究设计的初步研究来证实我们的发现。
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Association Between Helicobacter pylori Infection and Ulcerative Colitis: A Meta-Analysis Study
Background: Ulcerative colitis (UC), a chronic inflammatory disease that can cause bloody diarrhea, remains a major global disease burden. While Helicobacter pylori infection is postulated to be able to reduce the occurrence of UC, its role in the disease itself remains contentious. Hence, this meta-analysis aims to examine whether H. pylori infection can lower the chance of developing UC.Method: A systematic search was conducted through three electronic databases, namely Cochrane, PubMed, and Embase, with the addition of individual hand searching to analyze the association between ulcerative colitis and H. pylori infection in the adult population. Relevant articles selected through eligibility criteria were assessed for quality by using the Newcastle-Ottawa Scale. Furthermore, a random-effects meta-analysis was conducted to estimate the pooled odd ratios (ORs) along with their 95% confidence intervals (CIs). Higgins test  and funnel plots were also conducted.Results: A total of 11,498 patients with UC and 356,130 controls from 22 studies were included in the meta-analysis. Included studies showed fair or good quality. Good quality was achieved with the minimum score of 3 stars for selection, 1 star for comparability, and 2 stars for outcome/exposure, while fair quality was achieved with the minimum score of 2 stars for domain, 1 star for comparability, and 2 stars for outcome/exposure. Our findings indicated that H. pylori infection was associated with lower odds of UC [pooled ORs 0.51 (95% CI: 0.46-0.56)]), albeit moderate heterogeneity (I2= 54%, p = 0.002). Furthermore, publication bias was not found.Conclusion: The present study adds to the growing body of evidence supporting the potential protective effects of H. pylori infection on the occurrence of UC. However, further primary research with prospective study design needs to be conducted to confirm our findings.
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