最先进的方法和设备的产生,暴露,并从电子蒸汽产品的气溶胶收集

S. Boué, Didier Goedertier, J. Hoeng, A. Iskandar, A. Kuczaj, D. Marescotti, C. Mathis, Anne May, B. Phillips, M. Peitsch, W. Schlage, Davide Sciuscio, W. Tan, P. Vanscheeuwijck
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引用次数: 3

摘要

电子烟产品(EVP)已经成为吸烟者的流行替代品,否则他们会继续吸烟。EVP研究具有挑战性和复杂性,主要是因为市场上有许多快速发展的技术和设计,以及多种电子液体香料和溶剂。迫切需要规范EVP评估的所有阶段,从参考产品的生产到电子蒸汽产生方法,从物理化学表征方法到非临床和临床暴露研究。本综述的目的是详细描述EVP气溶胶产生、收集和暴露系统的实验设置和方法,以便对其进行体外和体内评估。重点是产品的特殊性,这些特殊性构成了挑战,需要开发特别评估框架、设备和方法。因此,本综述旨在支持进一步研究、客观评价、比较和验证现有证据,并最终制定检测evp的标准化方法。
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State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products
E-vapor products (EVP) have become popular alternatives for cigarette smokers who would otherwise continue to smoke. EVP research is challenging and complex, mostly because of the numerous and rapidly evolving technologies and designs as well as the multiplicity of e-liquid flavors and solvents available on the market. There is an urgent need to standardize all stages of EVP assessment, from the production of a reference product to e-vapor generation methods and from physicochemical characterization methods to nonclinical and clinical exposure studies. The objective of this review is to provide a detailed description of selected experimental setups and methods for EVP aerosol generation and collection and exposure systems for their in vitro and in vivo assessment. The focus is on the specificities of the product that constitute challenges and require development of ad hoc assessment frameworks, equipment, and methods. In so doing, this review aims to support further studies, objective evaluation, comparison, and verification of existing evidence, and, ultimately, formulation of standardized methods for testing EVPs.
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