{"title":"杂环5-甲氧基-2-苯氧恶唑-4-基锂的定向金属化:一种制备-脱氢氨基酸的方法","authors":"S. Chandrasekhar, M. Srimannarayana","doi":"10.1155/2010/452956","DOIUrl":null,"url":null,"abstract":"5-Methoxy-2-phenyloxazole was deprotonated at (by -BuLi or LDA, in THF at −78). The resulting anion was generally unreactive to alkylation (except methylation with MeI-TMEDA) but added to PhCHO and CHCHO. The alcohols thus produced dehydrated and ring opened in acid, to the corresponding ,-dehydroamino acids in moderate overall yields.","PeriodicalId":19688,"journal":{"name":"Organic Chemistry International","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Directed Metalation of Heterocycles, 5-Methoxy-2-phenyloxazol-4-yllithium: An Approach to ,-Dehydroamino Acids\",\"authors\":\"S. Chandrasekhar, M. Srimannarayana\",\"doi\":\"10.1155/2010/452956\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"5-Methoxy-2-phenyloxazole was deprotonated at (by -BuLi or LDA, in THF at −78). The resulting anion was generally unreactive to alkylation (except methylation with MeI-TMEDA) but added to PhCHO and CHCHO. The alcohols thus produced dehydrated and ring opened in acid, to the corresponding ,-dehydroamino acids in moderate overall yields.\",\"PeriodicalId\":19688,\"journal\":{\"name\":\"Organic Chemistry International\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Chemistry International\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2010/452956\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2010/452956","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Directed Metalation of Heterocycles, 5-Methoxy-2-phenyloxazol-4-yllithium: An Approach to ,-Dehydroamino Acids
5-Methoxy-2-phenyloxazole was deprotonated at (by -BuLi or LDA, in THF at −78). The resulting anion was generally unreactive to alkylation (except methylation with MeI-TMEDA) but added to PhCHO and CHCHO. The alcohols thus produced dehydrated and ring opened in acid, to the corresponding ,-dehydroamino acids in moderate overall yields.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
