Association between Renal Function and Diabetic Foot Ulcer in Type 2 Diabetic Patients

Background Diabetic nephropathy and diabetic foot syndrome (DFS) are two major diabetes complications . The aim of study to evaluate renal function in diabetic foot ulcers patients. Methods 75 adulttype2 DM patients were enrolled, divided into 2 groups , group 1 ,50 patients with active diabetic foot ulcer (DFU) and group 2 , 25 patients without , excluding diabetics with ESRD or undergoing hemodialysis. The number of DFU episodes and highest stages were recorded according to internationally accepted classifications of Wagner and Armstrong. Serum creatinine, urea, HbA1C, lipid profiles, urinalysis, urinary albumin/creatinine ratio. eGFR was estimated using (MDRD). Results DFU patients were older, exhibited higher HbA1c, longer diabetes duration, higher mean systolic blood pressure, higher serum creatinine and lower eGFR. Patients with DFU had higher incidence of complications. There was increased prevalence of foot ulcers by increasing degree of renal impairment. There was increased prevalence of foot ulcers with increasing degree of albuminuria. In group 1, there was significant correlation between Wagner stages of DFU and eGFR and Armstrong stages of DFU and eGFR. Conclusion There was strong association between degree of renal impairment and DFU. CKD diabetic patients should regularly be screened for DFS.