β-氨基丁酸对金黄色葡萄球菌感染大鼠血液学的调节作用

Zainab Agab, Mohammed A. Jasim, Atheer Zgair
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引用次数: 1

摘要

几项研究已经指导使用不同的化学物质作为抗生素的替代品,杀死细菌或可能导致刺激身体对感染的抵抗力,例如有机酸,其中包括非蛋白氨基酸,特别是β-氨基丁酸(ΒABA),在这项研究中已证明其能够增加雄性大鼠对金黄色葡萄球菌的全身抵抗力。以及增加白细胞和淋巴细胞的数量及其对改善免疫补体系统的积极作用。本研究的目的是了解β-氨基丁酸对金黄色葡萄球菌感染动物反应免疫系统的影响研究目的研究BABA治疗动物的血液学参数,包括:WBC、RBC、Hb、PCV、LYM、GRA本实验所用材料甘露醇盐场,以及血琼脂和麦康基琼脂分别用于培养金黄色葡萄球菌,以及不同浓度的氨基酸β-氨基丁酸制备第一种氨基酸浓度溶液(20 mg/ml)。另一种氨基酸按(40 mg/ml)的浓度配制,然后根据每只动物的体重配制所需剂量。BABA对(RBC- WBC -PLT - LYM-GRA)水平的影响结果表明,BABA对细菌感染组和BABA处理组的(RBC- mcv -PLT)水平无影响。结果表明,BABA对细菌感染组和BABA处理组的(WBC)水平无影响,但(LYM-GRA)百分比增加。
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Hematological Regulation Using β-aminobutyric Acid In Staphylococcus aureus infected Rats
Several studies have directed the use of different chemicals as an antibiotics alternative that kills bacteria or may lead to stimulating the body's resistance against infections, such as organic acids that include non-protein amino acids especially β-aminobutyric acid (ΒABA), which  has proven in this study its ability  to increase  the systemic resistance of male rats against  Staphylococcus aureus. As well as increasing the numbers of white blood cells and lymphocytes and their positive effect on improving the immune complement system . The aim of study was to know the effect of  β-aminobutyric Acid on the response immune system of animals that was infected  with   s. aureus bacteria Objectives of the study Study of hematological parameters of animals treated with BABA, including: WBC ,RBC , Hb , PCV ,LYM ,GRA     Materials used in  this experiment mannitol salt field, as well as blood agar and MacConkey agar were used for the development of Staphylococcus aureus bacteria, as well as amino acid β-aminobutyric Acid with different concentrations Prepare the first solution of amino acid concentration (20 mg/ml).The other amino acid was prepared at a concentration of (40 mg/ml)Then the required doses for each animal were prepared according to the weight of each animal Results: The effect of BABA on the level of  (RBC – WBC – PLT –LYM –GRA) The results showed that there was no effect of the amino acid BABA on the level of (RBC-MCV-PLT) in groups infected with bacteria and treated with BABAThe results showed that there was no effect of the amino acid BABA on the level of (WBC) in the groups infected with bacteria and treated with BABA, while the percentage of (LYM-GRA) increased.
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