自闭症青少年脑桥区听觉脑干异常反应

Q3 Medicine Neurology Psychiatry and Brain Research Pub Date : 2019-06-01 DOI:10.1016/j.npbr.2019.03.009

Emma Claesdotter-Knutsson , Sofia Åkerlund , Matti Cervin , Maria Råstam , Magnus Lindvall

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引用次数: 7

摘要

自闭症谱系障碍(ASD)是一种病因不明的损害性神经发育障碍。本研究旨在探讨诊断为ASD的儿童和青少年对复杂刺激的听觉脑干反应(ABR)是否可能成为自闭症的客观生物标志物。材料与方法对39例7 ~ 18岁青少年ASD的ABR与34例典型发育青少年(TD)的ABR进行比较。ABR由七个正峰(波I-VII)组成，在声音刺激后的10毫秒内出现。结果ASD组III波振幅(2.5 ~ 4.0 Ms区)高于TD组。与ASD组和TD女性相比，TD男性的左耳和右耳之间的相关性明显较低。结论与TD组相比，ASD组脑干桥脑区听觉加工明显受损。这些发现的意义讨论了神经生物学和青少年自闭症谱系障碍的评估。

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Abnormal auditory brainstem response in the pons region in youth with autism

Purpose of the article

Autism spectrum disorder (ASD) is an impairing neurodevelopmental disorder with an unknown etiology. The present study aims to investigate if the auditory brainstem response (ABR) to complex stimuli in children and adolescents diagnosed with ASD can be a possible objective biomarker in autism.

Materials and methods

The ABR of 39 youth with ASD (7–18 years) were compared to the ABR of 34 typically developed youth (TD). The ABR consists of seven positive peaks (waves I–VII) that occur during 10 Ms following a sound stimulus.

Results

The amplitude of wave III (region 2.5–4.0 Ms) was higher in the ASD group compared to the TD group. The TD males showed a significant lower degree of correlation, between left and right ear compared to the ASD groups and the TD females.

Conclusions

Altered auditory processing was evident in the pons region of the brainstem for the ASD group when compared to the TD group. Implications of the findings are discussed in relation to the neurobiology and assessment of autism spectrum disorder in youth.

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来源期刊

Neurology Psychiatry and Brain Research 医学-精神病学

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期刊介绍： Neurology, Psychiatry & Brain Research publishes original papers and reviews in biological psychiatry, brain research, neurology, neuropsychiatry, neuropsychoimmunology, psychopathology, psychotherapy. The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version. Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.