Emma Claesdotter-Knutsson , Sofia Åkerlund , Matti Cervin , Maria Råstam , Magnus Lindvall
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Abnormal auditory brainstem response in the pons region in youth with autism
Purpose of the article
Autism spectrum disorder (ASD) is an impairing neurodevelopmental disorder with an unknown etiology. The present study aims to investigate if the auditory brainstem response (ABR) to complex stimuli in children and adolescents diagnosed with ASD can be a possible objective biomarker in autism.
Materials and methods
The ABR of 39 youth with ASD (7–18 years) were compared to the ABR of 34 typically developed youth (TD). The ABR consists of seven positive peaks (waves I–VII) that occur during 10 Ms following a sound stimulus.
Results
The amplitude of wave III (region 2.5–4.0 Ms) was higher in the ASD group compared to the TD group. The TD males showed a significant lower degree of correlation, between left and right ear compared to the ASD groups and the TD females.
Conclusions
Altered auditory processing was evident in the pons region of the brainstem for the ASD group when compared to the TD group. Implications of the findings are discussed in relation to the neurobiology and assessment of autism spectrum disorder in youth.
期刊介绍：
Neurology, Psychiatry & Brain Research publishes original papers and reviews in
biological psychiatry,
brain research,
neurology,
neuropsychiatry,
neuropsychoimmunology,
psychopathology,
psychotherapy.
The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version.
Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.
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