{"title":"小鼠Brachyury (T)基因","authors":"Bernhard G. Herrmann","doi":"10.1016/S1044-5781(06)80002-2","DOIUrl":null,"url":null,"abstract":"<div><p>The isolation of the mouse <em>Brachyury (T)</em> gene has provided an important molecular tool for the investigation of mesoderm formation and axial development in vertebrates. The <em>T</em> gene is expressed specifically in nascent and early migrating mesoendoderm, and in notochord cells. It acts as a transcription factor controlling the differentiation of notochord cells, and the formation of mesoderm in the posterior of the embryo. Thus, mouse embryos lacking <em>T</em> function cannot undergo trunk nor tail formation. <em>T</em> plays distinct roles in the two cell types.</p></div>","PeriodicalId":101155,"journal":{"name":"Seminars in Developmental Biology","volume":"6 6","pages":"Pages 385-394"},"PeriodicalIF":0.0000,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1044-5781(06)80002-2","citationCount":"43","resultStr":"{\"title\":\"The mouse Brachyury (T) gene\",\"authors\":\"Bernhard G. Herrmann\",\"doi\":\"10.1016/S1044-5781(06)80002-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The isolation of the mouse <em>Brachyury (T)</em> gene has provided an important molecular tool for the investigation of mesoderm formation and axial development in vertebrates. The <em>T</em> gene is expressed specifically in nascent and early migrating mesoendoderm, and in notochord cells. It acts as a transcription factor controlling the differentiation of notochord cells, and the formation of mesoderm in the posterior of the embryo. Thus, mouse embryos lacking <em>T</em> function cannot undergo trunk nor tail formation. <em>T</em> plays distinct roles in the two cell types.</p></div>\",\"PeriodicalId\":101155,\"journal\":{\"name\":\"Seminars in Developmental Biology\",\"volume\":\"6 6\",\"pages\":\"Pages 385-394\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1044-5781(06)80002-2\",\"citationCount\":\"43\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in Developmental Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1044578106800022\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Developmental Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044578106800022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The isolation of the mouse Brachyury (T) gene has provided an important molecular tool for the investigation of mesoderm formation and axial development in vertebrates. The T gene is expressed specifically in nascent and early migrating mesoendoderm, and in notochord cells. It acts as a transcription factor controlling the differentiation of notochord cells, and the formation of mesoderm in the posterior of the embryo. Thus, mouse embryos lacking T function cannot undergo trunk nor tail formation. T plays distinct roles in the two cell types.
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