RISPR-Cas9:对抗COVID-19的武器

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摘要

在当前大流行形势下,新型冠状病毒对全世界都是一个有益的挑战,冠状病毒利用宿主细胞进行复制。冠状病毒通常使用宿主细胞产物来执行其基本功能。冠状病毒蛋白中还存在各种特异性靶点,用于靶向治疗,如病毒聚合酶的小抑制剂分子或用于疫苗接种目的的防止病毒附着在受体位点。病毒附着在ACE2受体上,利用酶来切割翻译产物,这些翻译产物编码各种酶,如RNA聚合酶,解旋酶等。系统需要一些过程来引起干扰,使病毒无法复制。重组DNA技术在生活的各个领域都取得了巨大的进步,在农业、工业和临床中具有重要意义。它用于操纵活生物体的遗传物质,以生产诸如抗病作物、治疗癌症、遗传疾病和病毒性疾病等理想产品。因此,为了抗病毒策略的目的,使用了称为CRISPR/Cas9的特定技术,该技术具有靶向冠状病毒基因组内特定核苷酸序列的能力。
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RISPR-Cas9: a weapon against COVID-19
In current pandemic circumstances, novel coronavirus is a salutary challenge for all over the world and coronavirus used the host cell for replication. Coronavirus usually use the host cellular products to perform their basic functions. Various specific target sites also present in coronavirus proteins for target-specific therapy such as small inhibitor molecule for viral polymerase or prevent the attachment of viruses to the receptor sites for vaccination purpose. The virus attaches to ACE2 receptors and uses enzyme to cleave translated products which encodes for various enzymes like RNA polymerase, helicase etc. The system needs some processes which lead for the disturbance and make the virus unable to replicate. The recombinant DNA technology makes a great advancement in every field of life with a number of importance in agriculture, industries, and clinics. It is used to manipulate the genetic material of living organism for the purpose of producing desirable products such as disease resistant crops, treatment of cancer, genetic disease and viral disease. Thus, for the purpose of antiviral strategies, the specific technique called CRISPR/Cas9 is used, and this technique has the capability to target specific nucleotide sequence inside the genome of coronavirus.
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