鸦片致癌性:实验研究的系统综述

Haniyeh Rafipour, E. Mohebbi, K. Zendehdel, S. Muhammadnejad, Paria Akbari, S. Hashemi, Kosar Nouri, F. Moradkhani, Tahereh Barati, S. Amanpour
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引用次数: 1

摘要

一些流行病学研究报告说,经常使用鸦片可能与患癌症的风险增加有关,包括食道癌、喉癌、膀胱癌、肺癌和胃癌。在这篇系统综述中,我们旨在调查实验研究是否支持这一发现,如果是的话,鸦片消费是如何导致癌症的。大多数研究鸦片及其衍生物的文章都发现它是一种致癌物质。然而,由于鸦片的成分复杂、形态各异、使用方式多样,需要进一步进行全面的实验研究。使用现代基因组学和表观基因组学方法似乎有助于确定鸦片致癌性的分子机制。
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Opium Carcinogenicity: A Systematic Review of Experimental Studies
Several epidemiological studies have reported that regular use of opium can be associated with an increased risk of developing cancers, including oesophageal, laryngeal, bladder, lung, and gastric cancer. In this systematic review, we aimed at investigating whether experimental studies support this finding and, if yes, how opium consumption can cause cancer. Most of the articles that have studied opium or its derivatives have found it as a carcinogen. However, due to the complex composition, different forms, and various ways of opium use, further comprehensive experimental studies are required. Using modern genomic and epigenomic methods seems to help determine the molecular mechanisms underlying opium carcinogenicity.
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