病毒和酒精在原发性肝癌发病机制中的作用

H. Inoue, H. Seitz
{"title":"病毒和酒精在原发性肝癌发病机制中的作用","authors":"H. Inoue, H. Seitz","doi":"10.1097/00008469-200102000-00016","DOIUrl":null,"url":null,"abstract":"Ž . Hepatocellular carcinoma HCC is one of the world’s most common cancers, causing almost one million deaths per year. A major risk factor for the development of HCC is liver cirrhosis. Epidemiological studies show that over 80% of HCCs worldwide Ž . occur in a cirrhotic liver Simonetti et al., 1997 . In some areas of Asia and Africa the incidence of HCC Ž . is up to 120 per 100 000 Muir et al., 1987 . In addition to cirrhosis of the liver, major risk factors Ž . for HCC are chronic hepatitis B virus HBV infection and chronic hepatitis C virus infection, as well as chronic consumption of alcohol. HCC in these patients occurs primarily in the accompanying cirrhosis. However, both viruses may also initiate HCC without cirrhosis. Other risk factors include aflatoxin B1 exposure and a variety of metabolic liver diseases Ž . Kountouras and Lygidakis, 2000 . The purpose of this review is briefly to discuss the link between HCV and HBV infection and HCC, some pathogenic aspects and also the role of alcohol in the development of HCC.","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2001-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"35","resultStr":"{\"title\":\"Viruses and alcohol in the pathogenesis of primary hepatic carcinoma.\",\"authors\":\"H. Inoue, H. Seitz\",\"doi\":\"10.1097/00008469-200102000-00016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ž . Hepatocellular carcinoma HCC is one of the world’s most common cancers, causing almost one million deaths per year. A major risk factor for the development of HCC is liver cirrhosis. Epidemiological studies show that over 80% of HCCs worldwide Ž . occur in a cirrhotic liver Simonetti et al., 1997 . In some areas of Asia and Africa the incidence of HCC Ž . is up to 120 per 100 000 Muir et al., 1987 . In addition to cirrhosis of the liver, major risk factors Ž . for HCC are chronic hepatitis B virus HBV infection and chronic hepatitis C virus infection, as well as chronic consumption of alcohol. HCC in these patients occurs primarily in the accompanying cirrhosis. However, both viruses may also initiate HCC without cirrhosis. Other risk factors include aflatoxin B1 exposure and a variety of metabolic liver diseases Ž . Kountouras and Lygidakis, 2000 . The purpose of this review is briefly to discuss the link between HCV and HBV infection and HCC, some pathogenic aspects and also the role of alcohol in the development of HCC.\",\"PeriodicalId\":11950,\"journal\":{\"name\":\"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"35\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/00008469-200102000-00016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/00008469-200102000-00016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 35

摘要

Ž。肝细胞癌是世界上最常见的癌症之一,每年造成近100万人死亡。肝癌发生的主要危险因素是肝硬化。流行病学研究表明,全世界80%以上的hcc Ž。Simonetti et al., 1997。在亚洲和非洲的一些地区,HCC的发病率Ž。Muir et al., 1987。除肝硬化外,主要危险因素Ž。慢性乙型肝炎病毒感染和慢性丙型肝炎病毒感染,以及慢性饮酒。这些患者的HCC主要发生在伴随的肝硬化中。然而,这两种病毒也可能引发没有肝硬化的HCC。其他危险因素包括黄曲霉毒素B1暴露和各种代谢性肝病Ž。Kountouras和Lygidakis, 2000。本文就HCV和HBV感染与HCC的关系、一些致病因素以及酒精在HCC发生中的作用作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Viruses and alcohol in the pathogenesis of primary hepatic carcinoma.
Ž . Hepatocellular carcinoma HCC is one of the world’s most common cancers, causing almost one million deaths per year. A major risk factor for the development of HCC is liver cirrhosis. Epidemiological studies show that over 80% of HCCs worldwide Ž . occur in a cirrhotic liver Simonetti et al., 1997 . In some areas of Asia and Africa the incidence of HCC Ž . is up to 120 per 100 000 Muir et al., 1987 . In addition to cirrhosis of the liver, major risk factors Ž . for HCC are chronic hepatitis B virus HBV infection and chronic hepatitis C virus infection, as well as chronic consumption of alcohol. HCC in these patients occurs primarily in the accompanying cirrhosis. However, both viruses may also initiate HCC without cirrhosis. Other risk factors include aflatoxin B1 exposure and a variety of metabolic liver diseases Ž . Kountouras and Lygidakis, 2000 . The purpose of this review is briefly to discuss the link between HCV and HBV infection and HCC, some pathogenic aspects and also the role of alcohol in the development of HCC.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
The PROPHET project paves the way for personalized prevention in the future healthcare. Prostate cancer burden in major BRICS countries, 1990-2019: findings from the 2019 global burden of disease study. Cancer mortality predictions for 2024 in selected Asian countries and Australia with focus on stomach cancer. Non-contrast MRI and post-mastectomy silicone breast implant rupture: preventing false positive diagnoses. Comment to: Inequalities in adherence to cervical cancer screening in Portugal.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1