银屑病靶向光疗的进展

A. Kawada
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引用次数: 2

摘要

牛皮癣是皮肤科中一种主要的炎症性疾病。光疗治疗寻常型银屑病安全有效。窄带紫外线(UV) B和补骨脂素加UVA被认为是常规非靶向光疗的常见方式。非靶向光疗对未受影响的皮肤进行不必要的照射,可能导致紫外线的长期不良影响。靶向光疗的优点,例如,对病变皮肤的高剂量,快速清除和缓解率较长,已经被开发出来。针对儿童、掌跖牛皮癣、头皮和指甲牛皮癣以及全身紫外线治疗后残留的难治性病变,优选光疗法。靶向光疗光源包括宽带UVB、窄带UVB、308 nm准分子激光及光、307 nm准分子光和312 nm平板荧光灯。本文综述了靶向光疗治疗银屑病的最新进展。
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Evolution of targeted phototherapy for psoriasis
Psoriasis is a major inflammatory disorder in the dermatological field. Phototherapy is effective and safe for psoriasis vulgaris. Narrow-band ultraviolet (UV) B and psoralen plus UVA are known to be the common modality as conventional non-targeted phototherapy. Non-targeted phototherapy making unnecessary irradiation to the unaffected skin may cause long-term adverse effects of UV. Targeted phototherapies with advantages, for example, higher dosages for lesional skin, a rapid clearing and longer remission rates, have been developed. Targeted phototherapies are preferably used for childhood, palmoplantar psoriasis, scalp and nail psoriasis as well as refractory lesions remained after whole-body UV therapy. Light sources of targeted phototherapy include broad-band UVB, narrow-band UVB, 308-nm excimer laser and light, 307-nm excimer light and 312-nm flat-type fluorescent lamp. This comprehensive review focuses recent evolution of target phototherapy for the treatment of psosriasis.
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