Soluble dietary fiber fraction of Trigonella foenum graecum seeds prevent olanzapine induced metabolic syndrome in rats

Trigonella foenum graecum TF belongs to the family Fabaceae it has been from ancient time used as a spice and traditionally ethno pharmacological medicine for promoting digestion and reduce blood sugar levels in a diabetic patient in India In the present study soluble dietary fiber SDF was isolated from TF seeds and investigates the role of SDF of TF against olanzapine induced metabolic complications Metabolic syndrome was induced by oral administration of OLZ mg kg in rats for days Then rats were treated with OLZ and SDFF of TF at and mg kg po day and metformin as a standard mg kg po day SDF of TF treatment significantly decreased body weight gain feed and water intake blood glucose oral glucose tolerance test OGTT lipid profile liver enzymes uric acid and improved hemodynamic parameters antioxidant status and reduced histopathological changes caused by OLZ treatment in rats SDF of TF increased the satiety suppresses appetite and improved the glucose and lipid metabolism and antioxidant potential exert the beneficial role in olanzapine induced metabolic syndrome